80569-59-1

Basic information

• Product Name: 4-methyl-5-phenyl-2H-1,2,3-triazole
• Synonyms: 4-methyl-5-phenyl-2H-1,2,3-triazole
• CAS NO: 80569-59-1
• Molecular Weight: 159.191
• Mol File: 80569-59-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-methyl-5-phenyl-2H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-5-phenyl-2H-1,2,3-triazole(80569-59-1)
• EPA Substance Registry System: 4-methyl-5-phenyl-2H-1,2,3-triazole(80569-59-1)

Safety Data

• Hazardous Substances Data: 80569-59-1(Hazardous Substances Data)

Upstream product

• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 79-24-3 Nitroethane 
• 100-52-7 benzaldehyde 
• 673-32-5 1-Phenylprop-1-yne 

Relevant articles and documents

Aluminium(III) Chloride-Catalyzed Three-Component Condensation of Aromatic Aldehydes, Nitroalkanes and Sodium Azide for the Synthesis of 4-Aryl-NH-1,2,3-triazoles

An aluminium(III) chloride-catalyzed three-component reaction of aromatic aldehydes, nitroalkanes, and sodium azide has been developed; this reaction sequence can be applied to a broad substrate scope and affords the corresponding 4-aryl-NH-1,2,3-triazoles in good to excellent yields. The milder reaction conditions and easier operation make this AlCl3-catalyzed protocol more advantageous for the synthesis of 4-aryl-NH-1,2,3-triazoles. (Figure presented.).

A high-efficient preparation NH - 1, 2, 3 triazole compounds

The invention discloses a method for efficiently preparing NH-1,2,3 triazole compound. An alkyne compound is used for being oxidized by an oxidizing agent, NaN3 or TMSN3 serves as a nitrogen source, the oxidizing agent is one of Ph(OAc)2, KMnO4, MnO2, PhI(CF3CO2)2, Mn(OAc)3, PhIO, (NH4)2Ce(NO3)6, and reaction is performed at indoor temperature to obtain the NH-1,2,3 triazole compound. The process of synthesizing the NH-1,2,3 triazole compound from simple alkyne and particularly electric neutrality or electron-rich alkyne is achieved, in this way, synthesis of the NH-1,2,3 triazole compound is more direct and simpler, and the potential application value of the NH-1,2,3 triazole compound is achieved better.

A NH - 1, 2, 3 - triazole synthetic method

The invention discloses a method for synthesizing NH-1,2,3-triazole shown by a formula (I). Under the catalytic action of a Lewis acid catalyst, nitroalkene shown by a formula (II) and hydrazoic acid salt undergo 1,3-dipolar cycloaddition, wherein Ar is p