80575-79-7Relevant articles and documents
Monobactams. Preparation of (S)-3-Amino-2-oxoazetidine-1-sulfonic Acids from L-α-Amino-β-hydroxy Acids via Their Hydroxamic Esters
Floyd, David M.,Fritz, Alan W.,Pluscec, Josip,Weaver, Eugene R.,Cimarusti, Christopher M.
, p. 5160 - 5167 (2007/10/02)
The cyclization of the O-methylhydroxamates 13-15 afforded excellent yields of the 1-methoxyazetidinones 16-18.Reductive cleavage of the methoxy group gave N-1-unsubstituted azetidinones 9, 19, and 20 which were sulfonated and deprotected, yielding zwitterions 29-31.These materials serve as general intermediates for the preparation of a large variety of monobactam antimicrobial agents.