80622-04-4Relevant academic research and scientific papers
Latent Inhibitors. Part 5. Latent Inhibition of Dihydrofolate Reductase by a Pteridine-spiro-cyclopropane
Haddow, John,Suckling, Colin J.,Wood, Hamish C. S.
, p. 1297 - 1304 (2007/10/02)
The design of cyclopropane-containing enzyme activated inhibitors of dihydrofolate reductase is presented.The synthesis of two examples, 2-amino-7,8-dihydro-6-hydroxymethylpteridine-7-spirocyclopropan-4(3H)-one and 2,4-diamino-5-(4-chlorophenyl)-6-cyclopropylpyrimidine, is described.Kinetic studies with dihydrofolate reductase from E. coli are presented to show that the former is a time-dependent inhibitor of the enzyme whereas the latter is a typical competitive inhibitor.The results are interpreted with regard to the active site structure of dihydrofolate reductase.
Preparation of Schiff bases of aminocycloalkanecarboxylic acids esters
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, (2008/06/13)
Schiff bases of aminocycloalkanecarboxylic acid esters of the formula STR1 where R, R1, R2, m and n have the meanings given in the description, are prepared by a novel process. The compounds are intermediates for the preparation of the corresponding aminocycloalkanecarboxylic acids and of esters thereof.
Compounds for the loosening of fruit and/or leaves on plants
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, (2008/06/13)
Compounds of the formula STR1 wherein R1 and R3 each is hydrogen or R1 and R3 together form a second carbon-to-nitrogen bond, R2 is hydrogen or cyano, R4 is alkyl and Ar is one of certain a
