80650-45-9

Basic information

• Product Name: 4-(PYRIDIN-3-YLOXY)-PHENYLAMINE
• Synonyms: ASINEX-REAG BAS 10148925;IFLAB-BB F2108-0080;4-(PYRIDIN-3-YLOXY)-PHENYLAMINE;TIMTEC-BB SBB010739;4-(pyridin-3-yloxy)aniline;4-(3-Pyridinyloxy)phenylamine;Albb-005633;4-(pyridin-3-yloxy)aniline(SALTDATA: FREE)
• CAS NO: 80650-45-9
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.21
• Mol File: 80650-45-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 98-105 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 346.2 °C at 760 mmHg
• Flash Point: 163.2 °C
• Appearance: /
• Density: 1.197 g/cm³
• Vapor Pressure: 5.84E-05mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.57±0.10(Predicted)
• CAS DataBase Reference: 4-(PYRIDIN-3-YLOXY)-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PYRIDIN-3-YLOXY)-PHENYLAMINE(80650-45-9)
• EPA Substance Registry System: 4-(PYRIDIN-3-YLOXY)-PHENYLAMINE(80650-45-9)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 80650-45-9(Hazardous Substances Data)

Usage

General Description

4-(pyridin-3-yloxy)-phenylamine is a chemical compound with the molecular formula C11H10N2O. It consists of a phenylamine group attached to a pyridine-3-yloxy moiety. 4-(PYRIDIN-3-YLOXY)-PHENYLAMINE is often used in organic synthesis and drug discovery due to its versatile reactivity and potential pharmacological activity. It can be employed as a building block for the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. Additionally, its unique structure and properties make it a valuable target for research in medicinal chemistry and chemical biology. Overall, 4-(pyridin-3-yloxy)-phenylamine is a valuable chemical with diverse applications in various fields of science and industry.

InChI:InChI=1/C11H10N2O/c12-9-3-5-10(6-4-9)14-11-2-1-7-13-8-11/h1-8H,12H2

Upstream product

• 109-00-2 3-HYDROXYPYRIDINE 
• 350-46-9 4-Fluoronitrobenzene 
• 636-98-6 p-nitrobenzene iodide 
• 28232-53-3 3-(4-nitro-phenoxy)-pyridine 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 1214468-35-5 2,4-dioxo-N-[4-(pyridin-3-yloxy)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY

The present invention provides a novel heterocyclic compound represented by Formula [I] and a salt thereof: wherein the symbols are as defined in the specification, which is useful for treating, preventing and/or diagnosing seizure and the like in disease involving epileptic seizure or convulsive seizure (including multiple drug resistant seizure, refractory seizure, acute symptomatic seizure, febrile seizure and status epilepticus), as well as a medical use therefor.

Synthesis and characterization of the first inhibitor of: N -acylphosphatidylethanolamine phospholipase D (NAPE-PLD)

N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quinazoline sulfonamide derivative 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide, ARN19874.

Synthesis of benzofuro[3,2-b]pyridines via palladium-catalyzed dual C-H activation of 3-phenoxypyridine 1-oxides

An efficient oxidative cyclization to straightforward synthesis of benzofuro[3,2-b]pyridine 1-oxides with high regioselectivity via Pd-catalyzed intramolecular dual C-H activation was developed. The resulting products could be deoxygenated easily to the corresponding benzofuro[3,2-b]pyridines in excellent yields.