80654-60-0

Upstream product

• 32970-77-7 2-phenyl-3-(p-tolyl)propanenitrile 
• 589-18-4 4-Methylbenzyl alcohol 
• 140-29-4 phenylacetonitrile 
• 106-42-3 para-xylene 
• 2700-22-3 Benzylidenemalononitrile 
• 69668-17-3 methyl 2-phenyl-3-(p-tolyl)propanoate 
• 104-81-4 4-Methylbenzyl bromide 
• 101-41-7 benzeneacetic acid methyl ester 

Downstream Products

• 1017443-93-4 2-Phenyl-3-p-tolyl-propionyl chloride 
• 80654-64-4 N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-phenyl-3-p-tolyl-propionamide 
• 80654-68-8 6,7-Dimethoxy-1-(1-phenyl-2-p-tolyl-ethyl)-3,4-dihydro-isoquinoline 
• 80654-72-4 6,7-Dimethoxy-1-(1-phenyl-2-p-tolyl-ethyl)-1,2,3,4-tetrahydro-isoquinoline 

Relevant academic research and scientific papers

AZABICYCLO AND DIAZEPINE DERIVATIVES FOR TREATING OCULAR DISORDERS

The present invention provides in one aspect azabicycio and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator. Formulae (I) & (II):

Metal-free direct alkylation of unfunctionalized allylic/benzylic sp3 C-H bonds: Via photoredox induced radical cation deprotonation

Despite notable recent efforts, a catalytic and convenient strategy for the direct alkylation of unactivated allylic or benzylic sp3 C-H bonds remains a formidable challenge facing the synthesis community. We herein report an unprecedented allylic/benzylic alkylation using only an organo-photoredox catalyst, which enables coupling of a broad scope of alkenes/arenes and electron-deficient alkenes in an atom-and redox-economic manner. A photoredox induced alkene/arene radical cation deprotonation is proposed to smoothly generate the key allylic and benzylic radical intermediates. It represents the first C-C bond formation via radical cation deprotonation under visible light conditions. The resulting products can be easily scaled up and directly converted to γ,δ-unsaturated or α,β-diaryl-acids,-esters,-amides,-pyrazoles,-isoxazoles, as well as lactones, which enables this mild and selective sp3 C-H alkylation to rapidly access complex bioactive molecules.

Atmosphere-Controlled Chemoselectivity: Rhodium-Catalyzed Alkylation and Olefination of Alkylnitriles with Alcohols

The chemoselective alkylation and olefination of alkylnitriles with alcohols have been developed by simply controlling the reaction atmosphere. A binuclear rhodium complex catalyzes the alkylation reaction under argon through a hydrogen-borrowing pathway and the olefination reaction under oxygen through aerobic dehydrogenation. Broad substrate scope is demonstrated, permitting the synthesis of some important organic building blocks. Mechanistic studies suggest that the alkylation product may be formed through conjugate reduction of an alkene intermediate by a rhodium hydride, whereas the formation of olefin product may be due to the oxidation of the rhodium hydride complex with molecular oxygen.

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))