80667-89-6Relevant academic research and scientific papers
Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates
Takahashi, Yasuko,Fuwa, Haruhiko,Kaneko, Akane,Sasaki, Makoto,Yokoshima, Satoshi,Koizumi, Hifumi,Takebe, Tohru,Kan, Toshiyuki,Iwatsubo, Takeshi,Tomita, Taisuke,Natsugari, Hideaki,Fukuyama, Tohru
, p. 3813 - 3816 (2007/10/03)
Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel γ-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arran
A chiron approach to (-)-tetrahydrolipstatin
Yadav,Vishweshwar Rao,Prasad
, p. 3888 - 3894 (2008/02/09)
An efficient chiron approach to the total synthesis of (-)- tetrahydrolipstatin is described. The main features of the synthetic strategy, which starts from tri-O-acetyl-D-glucal, are copper-mediated C-C bond formation, Frater alkylation, and Barton-McCombie deoxygenation. Georg Thieme Verlag Stuttgart.
Design and reactivity of organic functional groups - Preparation and nucleophilic displacement reactions of imidazole-1-sulfonates (imidazylates)
Vatele, Jean-Michel,Hanessian, Stephen
, p. 10557 - 10568 (2007/10/03)
Imidazole-1-sulfonate, a new type of leaving group by remote activation, allows facile S(N)2 substitution reactions at sterically crowded centers with various nucleophiles under mild conditions. It could be easily prepared from alcohols with cheap reagent
Negative-ion mass spectrometry of carbohydrates. A mechanistic study of the fragmentation reactions of dideoxy sugars
Binkley, Roger W.,Binkley, Edith R.,Duan, Shaoming,Tevesz, Michael J. S.,Winnik, Witold
, p. 879 - 895 (2007/10/03)
Hydroxyl group deprotonation of the a and β anomers of methyl 3-O-benzyl-2,6-dideoxy-D-arabino-hexopyranoside (1 and 2) occurs readily in the gas phase to produce the corresponding anions 3 and 4, respectively. Collisionally activated dissociation (CAD) o
DESIGN AND REACTIVITY OF ORGANIC FUNCTIONAL GROUPS: IMIDAZOLYLSULFONATE (IMIDAZYLATE) - AN EFFICIENT AND VERSATILE LEAVING GROUP
Hanessian, Stephen,Vatele, Jean-Michel
, p. 3579 - 3582 (2007/10/02)
The preparation and reactivity of the novel imidazolylsulfonate group is described.
