807361-70-2

Upstream product

• 100-39-0 benzyl bromide 
• 214468-42-5 p-methylphenyl 6-O-tert-butyldiphenylsilyl-1-thio-β-D-glucopyranoside 
• 106-45-6 para-thiocresol 
• 28244-94-2 p-tolyl-2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside 
• 604-69-3 β-D-glucose pentaacetate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1152-39-2 p-methylphenyl 1-thio-β-D-glucopyranoside 

Downstream Products

• 273935-03-8 2,3,4-tri-O-benzyl-6-O-tert-butyldiphenylsilyl-α-D-glucopyranosyl trichloroacetamidate 
• 158227-71-5 Hexadecanoic acid (S)-1-hexadecanoyloxymethyl-2-((2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-ethyl ester 
• 65493-32-5 3-O-(2,3,4-tri-O-benzyl-α-D-glucopyranosyl)-L-glycerol 
• 1207163-25-4 octyl 2,3,4-tri-O-benzyl-6-O-(tert-butyldiphenylsilyl)-α-D-glucopyranosyl-(1->6)-2-O-acetyl-3,4-O-isopropylidene-α-D-talopyranoside 
• 479252-05-6 ((2R,3R,4S,5R,6S)-3,4,5-Tris-benzyloxy-6-p-tolylsulfanyl-tetrahydro-pyran-2-yl)-methanol 

Relevant academic research and scientific papers

NOVEL NEISSERIA MENINGITIDIS SEROGROUP Y OLIGOMER AND PROCESS FOR SYNTHESIZING THEREOF

The present invention relates to novel oligomers of Neisseria meningitidis serogroup Y capsular polysaccharide repeating unit (Men-Y oligomers) and process for synthesizing novel Men- Y oligomers. In particular, the present invention relates to the chemic

Epimeric and amino disaccharide analogs as probes of an α-(1→6)mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesist

Mycobacterial lipoarabinomannan (LAM) is an important, immunologically active glycan found in the cell wall of mycobacteria, including the human pathogen Mycobacterium tuberculosis. At the core of LAM is a mannan domain comprised of α-(1→6)-linked-mannopyranose (Manp) residues. Previously, we and others have demonstrated that α-Manp-(1→6)- α-Manp disaccharides (e.g., Manp-(1→6)-α-ManpOctyl, 1) are the minimum acceptor substrates for enzymes involved in the assembly of the LAM mannan core. We report here the synthesis five epimeric and three amino analogs of 1, and their subsequent biochemical evaluation against an α-(1→6)-ManT activity present in a membrane preparation from M. smegmatis. Changing the manno- configuration of either residue of 1 to talo- or gluco- led to a reduction or loss of activity, thus confirming earlier work showing that the C-2 and C-4 hydroxyl groups of each monosaccharide were important for enzymatic recognition. Characterization of the products formed from these analogs was done using a combination of mass spectrometry and glycosidase digestion, and full substrate kinetics were also performed. The analogs in which the acceptor hydroxyl group had been replaced with an amino group were, as expected, not substrates for the enzyme, but were weak inhibitors. The Royal Society of Chemistry 2010.

Iterative one-pot synthesis of oligosaccharides

Straight to the point! Preactivation of a p-tolyl thioglycoside donor, followed by sequential addition of p-tolyl thioglycosyl acceptors in one reaction flask allowed rapid syntheses of oligosaccharides independent of anomeric reactivities of donors and a