807369-87-5

Basic information

• Product Name: (E)-3-(2-fluorophenyl)-prop-2-en-1-ol
• Synonyms: (E)-3-(2-fluorophenyl)-prop-2-en-1-ol
• CAS NO: 807369-87-5
• Molecular Weight: 152.168
• Mol File: 807369-87-5.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: (E)-3-(2-fluorophenyl)-prop-2-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-fluorophenyl)-prop-2-en-1-ol(807369-87-5)
• EPA Substance Registry System: (E)-3-(2-fluorophenyl)-prop-2-en-1-ol(807369-87-5)

Safety Data

• Hazardous Substances Data: 807369-87-5(Hazardous Substances Data)

Usage

General Description

The chemical (E)-3-(2-fluorophenyl)-prop-2-en-1-ol, also known as 2-fluoro-alpha-methylcinnamyl alcohol, is a colorless to pale yellow liquid with a molecular formula of C9H9FO. It is commonly used in the synthesis of pharmaceuticals, flavors, and fragrances. (E)-3-(2-fluorophenyl)-prop-2-en-1-ol possesses a double bond between the second and third carbon atoms, giving it a distinct geometric isomerism, where the two substituents on the carbon-carbon double bond are located on opposite sides of the bond. Its unique structure and properties make it an important building block in the production of various organic compounds and chemical products. Additionally, its fluorinated phenyl group enhances its biological and chemical activity, making it a valuable component in the development of new materials and medicinal compounds.

Upstream product

• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 446-52-6 2-Fluorobenzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 149733-71-1 (E)-3-(2-fluorophenyl)acrylaldehyde 
• 89760-42-9 (2E)-3-(2-fluorophenyl)prop-2-enoic acid ethyl ester 
• 58824-51-4 1-(2-fluorophenyl)-2-propen-1-ol 
• 18944-77-9 2-fluorocinnamic acid 
• 348-13-0 ethyl 3-(2-fluorophenyl)propenoate 
• 104201-65-2 methyl (2E)-3-(2-fluorophenyl)prop-2-enoate 
• 348-52-7 1-Fluoro-2-iodobenzene 

Downstream Products

• 918309-62-3 methyl (E)-(3-(2-fluorophenyl)allyl) carbonate 
• 149733-71-1 (E)-3-(2-fluorophenyl)acrylaldehyde 

Relevant articles and documents

New zampanolide mimics: Design, synthesis, and antiproliferative evaluation

Zampanolide is a promising microtubule-stabilizing agent (MSA) with a unique chemical structure. It is superior to the current clinically used MSAs due to the covalent nature of its binding to β-tubulin and high cytotoxic potency toward multidrug-resistan

Strong acid-catalyzed electrophilic ring expansion of oxetanes and sulfoxonium ylides

A strong protic acid-catalyzed electrophilic ring expansion of oxetanes into trans-2,3-disubstituted tetrahydrofuran derivatives using sulfoxonium ylides has been developed. This reaction produces functionalized trans-2,3-disubstituted tetrahydrofuran derivatives stereospecifically by using safe and stable sulfoxonium ylides without metal catalysts and the protection of inert gas.

Synthesis of Allylsilanes via Nickel-Catalyzed Cross-Coupling of Silicon Nucleophiles with Allyl Alcohols

NiCl2(PMe3)2-catalyzed reaction of allyl alcohols with silylzinc reagents, including PhMe2SiZnCl, Ph2MeSiZnCl, and Ph3SiZnCl, was performed, achieving allylsilanes in high yields. Aryl- and heteroaryl-substituted allyl alcohols, (E)-3-arylprop-2-en-1-ols, 1-aryl-prop-2-en-1-ols, and (E)-1-phenylpent-1-en-3-ol can be employed in the transformation. A range of functional groups as well as heteroaryl groups were tolerated. Reaction exhibited high regioselectivity and E/Z-selectivity when 1- or 3-aryl-substituted allyl alcohols were used as the substrates. Reaction of chiral allyl alcohol, (S,E)-1-phenylpent-1-en-3-ol, yielded a configuration-inversion product (R,E)-dimethyl(phenyl)(1-phenylpent-1-en-3-yl)silane.