80776-72-3

Upstream product

• 2446-62-0 7,8,9-trihydropyrido[2,1-b]quinazolin-11(6H)-one 
• 108-42-9 3-chloro-aniline 
• 675-20-7 piperidin-2-one 
• 2312-23-4 m-chlorophenylhydrazine hydrochloride 
• 368858-21-3 9,10,11,12-tetrahydro-4H-pyrido[2,1-b]quinazoline-4,9-dione 
• 118-92-3 anthranilic acid 
• 94271-23-5 α-benzylidene-2,3-tetramethylene-3,4-dihydroquinazol-4-one 

Relevant academic research and scientific papers

New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases

A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.

Nitrogen Bridgehead Compounds. Part 45. Synthesis of 6-Arylhydrazono-6,7,8,9-tetrahydro-11H-pyridoquinazolin-11-ones

A series of 6-arylhydrazono-6,7,8,9-tetrahydro-11H-pyridoquinazolin-11-ones 3-37, convenient starting materials for indolopyridoquinazolines, were prepared by diazonium coupling between aryldiazonium chlorides and 6,7,8,9-tetrahydro- 2, 6-formyl-6,7,8,9-tetrahydro- 39, 6-(dimethylamino)methylene-6,7,8,9- 38 or 6-carboxyl-6,7,8,9-tetrahydro-11H-pyridoquinazolin-11-ones 43.The arylhydrazono derivatives were also prepared from 6-bromo- 45 or 6,6-dibromo-6,7,8,9-tetrahydro-11H-pyridoquinazolines 46 with arylhydrazines.The structures of the 6-arylhydrazonopyridoquinazolines were characterized by uv and 1H nmr spectroscopy.The 6-arylhydrazono derivatives show a solvent-dependent E-Z isomerism.