80781-10-8 Usage
Uses
Used in Pharmaceutical Industry:
1-(4'-PYRIDINYL)-4-TOSYLIMIDAZOLE is used as a potential anti-cancer agent for its ability to target and potentially inhibit the growth of cancer cells. Its specific application reason is based on its chemical structure that allows it to interact with biological targets involved in cancer progression.
1-(4'-PYRIDINYL)-4-TOSYLIMIDAZOLE is also used as a potential anti-inflammatory agent, leveraging its chemical properties to modulate inflammation pathways and provide therapeutic benefits for conditions characterized by excessive inflammation.
Additionally, 1-(4'-PYRIDINYL)-4-TOSYLIMIDAZOLE serves as a compound of interest in the development of new pharmaceuticals, given its potential to be modified and optimized for various therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 1-(4'-PYRIDINYL)-4-TOSYLIMIDAZOLE is used as a starting material or a building block for the synthesis of more complex molecules with specific biological activities. Its unique structure makes it a valuable tool for exploring new chemical reactions and mechanisms, ultimately contributing to the advancement of drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 80781-10-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,7,8 and 1 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 80781-10:
(7*8)+(6*0)+(5*7)+(4*8)+(3*1)+(2*1)+(1*0)=128
128 % 10 = 8
So 80781-10-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H13N3O2S/c1-12-2-4-14(5-3-12)21(19,20)15-10-18(11-17-15)13-6-8-16-9-7-13/h2-11H,1H3
80781-10-8Relevant academic research and scientific papers
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles
Necardo, Cristiana,Alfano, Antonella Ilenia,Del Grosso, Erika,Pelliccia, Sveva,Galli, Ubaldina,Novellino, Ettore,Meneghetti, Fiorella,Giustiniano, Mariateresa,Tron, Gian Cesare
, p. 16299 - 16307 (2019/12/27)
Considering aryl azides as electrophilic partners for the TosMIC mediated Van Leusen reaction, a novel multicomponent synthesis of 4-tosyl-1-arylimidazoles is reported. In this transformation, two molecules of TosMIC participate in the reaction mechanism
Nucleophilic Displacement of Primary Amino Groups via 1-Substituted 4-Tosylimidazoles
Taylor, Edward C.,LaMattina, John L.,Tseng, Chi-Ping
, p. 2043 - 2047 (2007/10/02)
Two methods are discribed for the replacement of primary amino groups, situated either α or γ to a heterocyclic nitrogen atom, by ethoxy, alkylthio, and arylthio substituents, by Wittig reagents, and by hydrogen.Both methods involve transformation of the primary amino group into a nucleofugic pendant heterocycle.The first converts the primary amino group into a 5-phenyl-1-tetrazolyl substituent by benzoylation, formation of the imidoyl chloride, and reaction with sodium azide, while the second converts the primary amino group into a 1-(4-tosylimidazolyl) substituent by reaction with triethyl orthoformate and acid to give the (ethoxymethylene)amino derivative, which is then condensed with tosylmethyl isocyanide (TosMIC) anion.The 1-(4-tosylimidazolyl) substituent is shown to be more susceptible to nucleophilic displacement by a wider range of nucleophiles.
