80815-65-2

Usage

Also Known As

4-Methylphenyl glyoxaline

Primary Use

Building block in the synthesis of pharmaceuticals and agrochemicals.

Applications

Pharmaceuticals: Used in the synthesis of various drugs.
Agrochemicals: Plays a role in the creation of agricultural chemicals.
Organic Synthesis: Acts as a reactive intermediate.

Potential Applications

Drug Development: Contributes to the creation of new medications.

Handling

Caution Required: Hazardous if not used properly.

Upstream product

• 55581-67-4 3-(4'-methylphenyl)isoxazoline 
• 3235-02-7 p-methylbenzaldehyde oxime 
• 36288-37-6 N-hydroxy-4-methylbenzenecarboximidoyl chloride 
• 143407-58-3 (Z)-2-(4,5-Dihydro-oxazol-2-yl)-1-p-tolyl-vinylamine 
• 104-85-8 para-methylbenzonitrile 

Relevant academic research and scientific papers

Synthesis and reactivity of β-amino-α,β-unsaturated oxa- and thiazolines

A simple and efficient route to masked β-amino-α,β-unsaturated acids 3 by reaction of metalated oxa- and thiazolines with nitriles has been developed. The reactivity of 3 has also been explored.

PHOTOCHEMISTRY OF 3-ARYL-2-ISOXAZOLINE

3-Phenyl-2-isoxazoline (1) was irradiated to give 4-phenyl-2-oxazoline (3), β-aminoaldehyde (14) and benzonitrile from its ?-?* singlet excited state.Several related derivatives afforded similar photoproducts on irradiation.The quantum yields of the photoreactions were dependent on the magnitudes of the singlet energies of the 2-isoxazolines. p-Cyanophenyl-2-isoxaline (1c) formed a one-to-one photoadduct (22) with benzene.