80817-35-2

Upstream product

• 96404-99-8 cyclohexylammonium 2-chlorophenyl 2-cyanoethyl phosphate 
• 67219-55-0 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 
• 80817-46-5 bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate 
• 109-78-4 3-Hydroxypropionitrile 
• 76964-04-0 [1,2,4]Triazol-1-yl-phosphonic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 15074-54-1 2-chlorophenyl dichlorophosphate 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 3992-42-5 2'-deoxycytidine monohydrochloride 
• 72351-28-1 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) 
• 4836-13-9 N₄-benzoyl-2'-deoxycytidine 
• 31501-22-1 N⁴-benzoyl-1-(3',5'-di-O-benzoyl-2'-deoxy-β-D-ribofuranosyl)-cytosine 
• 96404-97-6 2-chlorophenyl bis<2-cyanoethyl>phosphate 

Downstream Products

• 81187-02-2 4,4'-dimethoxytrityl-4-N-benzoyl-2'-deoxycytidine-3'-O-(2-chlorophenyl)phosphate 
• 80817-38-5 N⁴-benzoyl-2'-deoxycytidine-3'-O-(2-chlorophenyl-2-cyanoethyl)phosphate 
• 85240-13-7 C₆₃H₆₀Cl₂N₈O₁₇P₂ 
• 85240-12-6 C₆₃H₆₀Cl₂N₈O₁₇P₂ 
• 78098-93-8 C₆₆H₆₃Cl₂N₉O₁₇P₂ 
• 78111-51-0 C₆₆H₆₃Cl₂N₉O₁₇P₂ 
• 75251-87-5 N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2'-deoxycytidylyl-(3'->5')-N-benzoyl-2'-deoxy-3'-cytidylic acid, 2-chlorophenyl 2-cyanoethyl ester 
• 75269-18-0 N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'->5')-N-benzoyl-2'-deoxy-3'-cytidylic acid, 2-chlorophenyl 2-cyanoethyl ester 
• 78150-12-6 C₆₂H₅₈Cl₂N₆O₁₇P₂ 
• 95061-24-8 C₅₉H₅₅Cl₂N₅O₁₇P₂*C₆H₁₅N 

Relevant academic research and scientific papers

Improved Synthesis of Oligodeoxyribonucleotides by Solid-Phase Phosphotriester Method Utilizing O6--2'-deoxyguanosine Derivatives

The synthesis of oligodeoxyribonucleotides on a cross-linked polystyrene solid support utilizing stable mono- and dinucleotide phosphotriester building blocks is presented.The use of O6--2'deoxyguanosine derivatives yields cleaner DNA fragments by supressing side reactions.Modifications improving the phosphotriester methodology are presented.The purification methods and analysis of synthetic oligodeoxyribonucleotides are described.

Simplified Liquid-Phase Preparation of Four Decadeoxyribonucleotides and their Preliminary Spectroscopic Characterization

Four self-complementary decadeoxyribonucleotides, dApTpApTpApTpApTpApT,dApTpApTpCpGpApTpApT, dApTpApTpGpCpApTpApT and dApApApApApTpTpTpTpT, were chemically synthesized by the phosphotriester procedure.Efforts were concentrated on keeping the procedure as simple as possible, concomitant with obtaining high-purity products at each step of the process.The decamers were elaborated from the 3'-end, starting with a 3'-O-benzoylated monomer according to the scheme: monomer + monomer -> dimer + dimer -> tetramer + dimer -> hexamer + tetramer -> decamer.Putity of intermediates and of the fully blocked decamers were monitored by chromatography and by 300-MHz 1H-NMR. spectroscopy.The deblocked decadeoxyribonucleotides were characterized by their UV., CD., and 1H-NMR. spectra.