808170-24-3

Upstream product

• 357436-78-3 N-(4-amino-2-benzoylphenyl)-trifluoroacetic acid amide 
• 847147-46-0 (E)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid chloride 
• 62806-39-7 3-<5-(4-Nitrophenyl)-2-furyl>propenoic acid 
• 313499-48-8 N-(2-benzoyl-4-nitrophenyl)trifluoroacetamide 
• 1775-95-7 2-amino-5-nitrobenzophenone 

Downstream Products

• 847147-39-1 [(2-benzoyl-4-{3-[5-(4-nitro-phenyl)-furan-2-yl]-acryloylamino}-phenylcarbamoyl)-(4-trifluoromethyl-phenyl)-methyl]-carbamic acid tert-butyl ester 
• 847147-38-0 [(2-benzoyl-4-{3-[5-(4-nitro-phenyl)-furan-2-yl]-acryloylamino}-phenylcarbamoyl)-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester 
• 847147-36-8 [(S)-(2-Benzoyl-4-{(E)-3-[5-(4-nitro-phenyl)-furan-2-yl]-acryloylamino}-phenylcarbamoyl)-phenyl-methyl]-carbamic acid tert-butyl ester 
• 847147-37-9 [(R)-(2-Benzoyl-4-{(E)-3-[5-(4-nitro-phenyl)-furan-2-yl]-acryloylamino}-phenylcarbamoyl)-phenyl-methyl]-carbamic acid tert-butyl ester 
• 605636-80-4 (E)-N-(4-amino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amide 
• 866835-68-9 (E)-(RS)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbony-4-trifluoromethylphenylalanine amide 
• 866835-66-7 (E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide 
• 866835-64-5 (E)-(S)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide 

Relevant academic research and scientific papers

Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3- benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity

Water solubility was previously found to be essential for in vivo-antimalarial activity of a novel type of benzophenone-based farnesyltransferase inhibitors. Introduction of a α-amino group into the phenylacetic acid substructure provided more soluble compounds with high farnesyltransferase inhibitory activity. The in vitro-antimalarial activity was detrimentally influenced by this structural modification.

Non-thiol farnesyltransferase inhibitors: N-(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.

We have designed the nitrophenylfurylacryl-substituted benzophenone 4f as a non-thiol farnesyltransferase inhibitor utilizing a novel aryl binding site of farnesyltransferase. Variation of the 2-acylamino substituent at the benzophenone core structure of

Structure-activity relationships of novel anti-malarial agents. Part 6: N-(4-arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

We have demonstrated that the p-trifluoromethylphenylpropionylamino residue at the 2-position of the core structure leads to an active benzophenone-type anti-malarial agent. The attempt to improve water solubility by introduction of an amino group into th