80825-28-1

Upstream product

• 54029-45-7 2-nitro-4-thiocyanoaniline 
• 7647-01-0 hydrogenchloride 
• 88-74-4 2-nitro-aniline 
• 54029-46-8 acetic acid-(2-nitro-4-thiocyanato-anilide) 
• 3321-94-6 N-(4-thiocyanatophenyl)acetamide 
• 2987-46-4 4-thiocyanatoaniline 

Downstream Products

• 54393-89-4 1-amino-2-nitro-4-n-propylthiobenzene 
• 78212-93-8 bis(3,4-diaminophenyl) disulfide 

Relevant academic research and scientific papers

Synthesis of 2-amino-5(6)-(4-aminophenyl)benzimidazole derivatives: II. Reaction of 2-nitro-4-thiocyanatoaniline with 4-nitrochlorobenzene

The reaction of 2-nitro-4-thiocyanatoaniline with 4-nitrochlorobenzene in aqueous alkaline medium in the presence of phase-transfer catalyst at 95-100°C was studied with a view to obtain 4-amino-3,4′- dinitrodiphenyl sulfide. Optimal conditions for the synthesis and isolation of the product were found.

Preparation method of 4-propythio-2-nitroaniline

The invention discloses a preparation method of 4-propythio-2-nitroaniline, and solves the technical problems of unreasonable preparation method, high raw material price, high toxicity, complex operation, high cost, large production of three wastes, low yield and unsuitability for industrial production in the prior art. The preparation method of 4-propythio-2-nitroaniline provided by the inventiontakes o-nitroaniline, disulfur dichloride and chloropropane as the raw materials, and carries out condensation reaction and alkylation reaction in order under the action of a catalyst so as to obtain4-propythio-2-nitroaniline. The method can be widely applied technical field of synthesis of albendazole.