7017-52-9

Basic information

• Product Name: 4-BROMO-2-(CHLOROMETHYL)-1-METHOXYBENZENE
• Synonyms: 4-BROMO-2-(CHLOROMETHYL)-1-METHOXYBENZENE;Benzene, 4-broMo-2-(chloroMethyl)-1-Methoxy-
• CAS NO: 7017-52-9
• Molecular Formula: C₈H₈BrClO
• Molecular Weight: 235.51
• Mol File: 7017-52-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 279.948°C at 760 mmHg
• Flash Point: 123.109°C
• Appearance: /
• Density: 1.497g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 4-BROMO-2-(CHLOROMETHYL)-1-METHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(CHLOROMETHYL)-1-METHOXYBENZENE(7017-52-9)
• EPA Substance Registry System: 4-BROMO-2-(CHLOROMETHYL)-1-METHOXYBENZENE(7017-52-9)

Safety Data

• Hazardous Substances Data: 7017-52-9(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-(chloromethyl)-1-methoxybenzene is a chemical compound with the molecular formula C8H8BrClO. It is a benzene derivative containing a bromine atom, a chlorine atom, and a methoxy (CH3O) group. 4-BROMO-2-(CHLOROMETHYL)-1-METHOXYBENZENE is commonly used in organic synthesis and pharmaceutical research due to its potential for forming various kinds of carbon-carbon, carbon-oxygen, and carbon-halogen bonds. It is also utilized in the manufacturing of agrochemicals, pharmaceuticals, and other specialty chemicals. However, it is important to handle this compound with care as it may be hazardous if not properly managed.

InChI:InChI=1/C8H8BrClO/c1-11-8-3-2-7(9)4-6(8)5-10/h2-4H,5H2,1H3

Upstream product

• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 2316-64-5 5-bromo-2-hydroxybenzyl alcohol 
• 80866-82-6 5-bromo-2-methoxy-benzyl alcohol 
• 50-00-0 formaldehyd 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 33839-11-1 4-bromo-2-ethyl-1-methoxybenzene 
• 82547-30-6 3-(5-bromo-2-methoxyphenyl) propanoic acid 
• 14804-31-0 2-methyl-4-bromoanisole 
• 178363-65-0 4-bromo-2-propyl-anisole 
• 7062-40-0 1-(cyanomethyl)-2-methoxy-6-bromobenzene 
• 41876-52-2 2-benzyl-4-bromoanisole 
• 80866-82-6 5-bromo-2-methoxy-benzyl alcohol 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 2476-35-9 5-bromo-2-methoxybenzoic acid 
• 179260-93-6 2-[(4-(2-pyrimidinyl)-piperazinyl)methyl]-4-bromoanisole 
• 14804-38-7 5-bromo-2-methoxy-1,3-dimethylbenzene 
• 505070-85-9 1-(3-dimethylaminomethyl-4-methoxyphenyl)ethanone 
• 7078-90-2 (5-bromo-2-methoxybenzyl)dimethylamine 

Relevant articles and documents

First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate

Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing these diseases. We previously developed several classes of 2-aminoquinoline-based nNOS inhibitor

ANTI-FIBROTIC COMPOUNDS

Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein. (Formula (I))

Design and Synthesis of New Naphthalenic Derivatives as Ligands for 2-Iodomelatonin Binding Sites

New melatonin-like agents were designed from the frameworks of 2,5-dimethoxyphenethylamine, an important structural moiety for the 5-HT receptor, and (2-methoxynaphthyl)ethylamine.The compounds were synthesized by classical methods and evaluated in binding assays with chicken brain membranes using 2-(125I>iodomelatonin as the radioligand.Preliminary studies on the series of N-acyl-disubstituted phenethylamines showed the favorable role of the methoxy group in the ortho position of the side chain on the affinity for the receptor ( Ki = 8 +/- 0.2 nM ) for N-propionamide (3o).This effect was confirmed in a series of the naphthalene derivatives, a bioisosteric moiety of the indole ring, and several potent ligands for melatonin binding sites were prepared such as N-propionamide (4b) ( Ki = 0.67 +/- 0.05 nM ) and N-cyclopropylformamide (Ki = 0.05 +/- 0.004 nM ( (4k).Structure-activity relationships are discussed with regard to melatonin and bioisosteric naphthalenic compound 2.The Ki value for 4b was affected to a similar extent to that of melatonin by GTP-γ-S or Mn2+ in competition experiments, suggesting an agonist profile for this compound.