808732-87-8

Upstream product

• 86169-24-6 2-amino-(2-chlorophenyl)ethanoic acid 
• 85567-51-7 2-(thiophene-2-yl)ethyl benzenesulfonate 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 26118-14-9 o-chlorobenzoylformic acid 
• 29270-30-2 α-bromo-2-chlorophenyl acetic acid 
• 2444-36-2 2'-chloro-benzeneacetic acid 

Downstream Products

• 1015247-86-5 (+/-)-N-(2-(2-thienyl)ethyl)-2-chlorophenyl glycine hydrochloride 
• 90055-55-3 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid 

Relevant academic research and scientific papers

Clopidogre and wherein the intermediate α-bromo-ortho-chlorophenyl acetic acid and α-thiophene substituted ethylamino- method for the preparation of acetic acid hydrochloride (by machine translation)

The invention discloses a preparation method of clopidogrel and intermediates thereof. The preparation method of the clopidogrel and intermediates thereof, provided by the invention, has the characteristics of being simple to operate, mild in reaction condition, little in pollution, low in energy consumption and the like and is suitable for industrial production, a high-purity intermediate can be provided for production of the clopidogrel, and the production cost of the clopidogrel is reduced.

PROCESS FOR THE SYNTHESIS OF CLOPIDOGREL AND NEW FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

The present invention relates to a new process for the preparation of clopidogrel and to new polymorphic forms of clopidogrel salts, to processes for their preparation and to a pharmaceutical formulation containing the new forms.