808753-00-6

Basic information

• Product Name: 2-(2-aminomethyl-phenyl)-N-methyl-N-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-acetamide
• Synonyms: 2-(2-aminomethyl-phenyl)-N-methyl-N-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-acetamide
• CAS NO: 808753-00-6
• Molecular Weight: 351.492
• Mol File: 808753-00-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-aminomethyl-phenyl)-N-methyl-N-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-aminomethyl-phenyl)-N-methyl-N-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-acetamide(808753-00-6)
• EPA Substance Registry System: 2-(2-aminomethyl-phenyl)-N-methyl-N-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-acetamide(808753-00-6)

Safety Data

• Hazardous Substances Data: 808753-00-6(Hazardous Substances Data)

Upstream product

• 749832-15-3 methyl 2-(2-(aminomethyl)phenyl)acetate 
• 147410-31-9 methyl 2-(N-(tert-butoxycarbonyl)aminomethyl)phenylacetate 
• 116508-51-1 (1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 18698-97-0 ortho-bromophenylacetic acid 
• 40851-66-9 2-(tert-butoxycarbonylaminomethyl)phenylacetic acid 
• 808752-99-0 [2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

Some κ opioid receptor agonists of the arylacetamide class, for example, ICI 199441 (1), were found to strongly inhibit the activity of cytochrome P450 2D6 (CYP2D6) (1: CYP2D6 IC50 = 26 nM). Certain analogs bearing a substituted sulfonylamino group, for example, 13, were discovered to have significantly reduced CYP2D6 inhibitory activity (13: CYP2D6 IC50 > 10 μM) while displaying high affinity toward the cloned human κ opioid receptor, good κ/δ and κ/μ selectivity, and potent in vitro and in vivo agonist activity.