80880-38-2Relevant academic research and scientific papers
REGIOSPECIFIC INTRODUCTION OF ALKYL GROUPS INTO 4-POSITION OF PYRIDINE. NOVEL SYNTHESIS OF 4-SUBSTITUTED PYRIDINES
Akiba, Kin-ya,Matsuoka, Hideto,Wada, Makoto
, p. 4093 - 4096 (1981)
Regiospecific synthesis of 4-substituted pyridines is attained via alkylation of diisopropyl 1-ethoxycarbonyl-1,4-dihydropyridine-4-phosphonate followed by treatment with butyllithium.The phosphonate is prepared directly from pyridine in one pot.
