REGIOSPECIFIC INTRODUCTION OF ALKYL GROUPS INTO 4-POSITION OF PYRIDINE. NOVEL SYNTHESIS OF 4-SUBSTITUTED PYRIDINES

DOI: 10.1016/S0040-4039(01)82074-8

Source and publish data:

Tetrahedron Letters p. 4093 - 4096 (1981)

Update date:2022-08-02

Topics:

Authors:

Akiba, Kin-ya

Matsuoka, Hideto

Wada, Makoto

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Article abstract of DOI:10.1016/S0040-4039(01)82074-8

Regiospecific synthesis of 4-substituted pyridines is attained via alkylation of diisopropyl 1-ethoxycarbonyl-1,4-dihydropyridine-4-phosphonate followed by treatment with butyllithium.The phosphonate is prepared directly from pyridine in one pot.

Full text of DOI:10.1016/S0040-4039(01)82074-8

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