REGIOSPECIFIC INTRODUCTION OF ALKYL GROUPS INTO 4-POSITION OF PYRIDINE. NOVEL SYNTHESIS OF 4-SUBSTITUTED PYRIDINES

Article abstract of DOI:10.1016/S0040-4039(01)82074-8

Regiospecific synthesis of 4-substituted pyridines is attained via alkylation of diisopropyl 1-ethoxycarbonyl-1,4-dihydropyridine-4-phosphonate followed by treatment with butyllithium.The phosphonate is prepared directly from pyridine in one pot.