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Usage

Uses

Used in Pharmaceutical Industry:
Trans-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid-HCl is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure and properties allow it to be a valuable component in the development of new medications.
Used in Medicinal Chemistry Research:
Trans-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid-HCl is used as a research compound in medicinal chemistry. Its ability to interact with biological systems and modulate specific pathways makes it a promising candidate for the study of drug mechanisms and the development of novel therapeutic agents.

InChI:InChI=1/C18H18ClNO2/c19-15-8-6-14(7-9-15)16-11-20(12-17(16)18(21)22)10-13-4-2-1-3-5-13/h1-9,16-17H,10-12H2,(H,21,22)/t16-,17+/m1/s1

Upstream product

• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 20026-96-4 ethyl 3-(4-chlorophenyl)propiolate 
• 1229236-32-1 1-Benzyl-4-(4-chloro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 63757-30-2 ethyl (Z)-3-(4-chlorophenyl)acrylate 

Relevant academic research and scientific papers

PYRROLIDINE DERIVATIVES

The present invention relates to compounds of formula wherein R1, R2, R3, R4, Z, and n are as defined herein or to a pharmaceutically active salt thereof. Compounds of the invention are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).

PYRROLIDINE DERIVATIVES

The present invention relates to compounds of formula (I) or to a pharmaceutically active salt thereof. It has been found that the present compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's

PROCESS FOR THE PREPARATION OF PYROLLIDINE-3-CARBOXYLIC ACIDS

The invention relates to a novel process for the preparation of (3S,4S)- or (3R,4R)-1-benzyl-4-(halogen-aryl)-pyrrolidine-3-carboxylic acids of formula I or salts thereof, wherein X and Y are each independently hydrogen or a halogen atom, with the proviso that at least one of X or Y is a halogen atom. The compounds of formula I are useful as starting materials or intermediates for the preparation of pharmaceutically active compounds, especially for compounds, which are useful for the treatment of central nervous system disorders.

PYRROLIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS

The present invention relates to a compounds of formula I wherein A, Ar, R, R2, R3, R4, p, and o are as defined in the specification and claims or to a pharmaceutically active salt thereof. The present compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, bipolar disorders, anxiety and attention deficit hyperactivity disorder (ADHD).

Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor

A series of trans-N-alkyl-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanemethylamines was synthesized and characterized for binding and function at the melanocortin-4 receptor (MC4R), and several potent benzylamine derivatives were i

The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist

5-HT2C agonists have shown efficacy in limiting food consumption and thus may serve as an important drug class in combating obesity. We describe the design and synthesis of a novel tricyclic single-nitrogen scaffold that was used to produce 5-HT2C agonists. SAR was developed around this chemotype and compounds were identified that were potent (Ki 2 receptors. The most promising compound displayed a good pharmacokinetic profile in multiple animal species, and was efficacious in an acute feeding study in rats.

Synthesis of Phenyl- and Benzyl-Substituted Pyrrolidines and of a Piperidine by Intramolecular C-Alkylation. Synthons for Tricyclic Skeletons

The construction of new or novelly functionalized annulated and bridged tricyclic compounds by two consecutive C,C-bond formations (a and b in 1a, Scheme 1) is described.In a first step, Chloroalkyl-substituted aminonitriles yielded pyrrolidines 8, 15a, 1