80907-78-4Relevant academic research and scientific papers
A simple primary amine catalyst for enantioselective α-hydroxylations and α-fluorinations of branched aldehydes
Witten, Michael R.,Jacobsen, Eric N.
, p. 2772 - 2775 (2015)
A new primary amine catalyst for the asymmetric α-hydroxylation and α-fluorination of α-branched aldehydes is described. The products of the title transformations are generated in excellent yields with high enantioselectivities. Both processes can be performed within short reaction times and on gram scale. The similarity in results obtained in both reactions, combined with computational evidence, implies a common basis for stereoinduction and the possibility of a general catalytic mechanism for α-functionalizations. Promising initial results in α-amination and α-chlorination reactions support this hypothesis.
Synthesis of 2-arylacrylic esters from aryl methyl ketones via Wittig reaction/singlet oxygen ene reaction
Park, Sangjoon,Yang, Dongsik,Kim, Kyoung Tae,Jeon, Heung Bae
scheme or table, p. 6578 - 6580 (2011/12/22)
An efficient synthetic method has been developed for the synthesis of 2-arylacrylic esters from the corresponding aryl methyl ketones via Wittig reaction and singlet oxygen ene reaction. Wittig reaction to aryl methyl ketones with (methoxymethyl)triphenyl
Diazoethenes: Their Attempted Synthesis from Aldehydes and Aromatic Ketones by Way of the Horner-Emmons Modification of the Wittig Reaction. A Facile Synthesis of Alkynes
Gilbert, J. C.,Weerasooriya, U.
, p. 1837 - 1845 (2007/10/02)
The base-promoted reaction of dimethyl (diazomethyl)phosphonate (8) with aldehydes and aryl ketones at low temperatures has been investigated.Alkynes, in modest to excellent yields, are the predominant products of these reactions, a result consistent with the intervention of diazoethenes (3).The latter appear to be unstable toward unimolecular decomposition at -78 deg C and yield nitrogen and alkylidenecarbenes (1).
