80912-09-0Relevant articles and documents
A Novel Synthesis of Purine and Deazapurine Derivatives from 5-Aminoimidazoles
Al-Shaar, Adnan H.,Gilmour, David J.,McClenaghan, Ian,Ramsden, Christopher A.
, p. 551 - 552 (1989)
Ccatalytic reduction of 4-unsubstituted-5-nitroimidazoles (3) in 1,4-dioxane solution is an excellent route to the 5-aminoimidazoles (1) which can be isolated or used in situ to generate good yields of purine or deazapurine derivatives.
Deacetylcolchicine deriv.
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Paragraph 0463, (2016/10/08)
Provided are 4-modified colchicine compounds and medicines using the same. Specifically provided are colchicine derivatives represented by general formula (1), salts thereof, and solvates of the same. In general formula (1), R1 is a halogen atom, a hydroxyl group, a nitro group, an amino group, or a mono-, di- or tri-fluoromethyl group; R2, R3 and R4 are each a methoxy group or a hydroxyl group, or alternatively R2 and R3, or R3 and R4 together represent a methylenedioxy group; R5 and R6 may be the same or different and are each a hydrogen atom, a C1-6 alkyl group, an arylalkyl group, a C2-6 alkenyl group, -COR7, -COOR8, -SO2R9, -CONR10R11, or -CSNR12R13, or alternatively R5 and R6 together with the nitrogen atom to which R5 and R6 are bonded may form a three- to seven-membered cyclic amino group; R7 is a C1-6 alkyl group or the like; R8 is a C1-6 alkyl group or the like; R9 is a C1-6 alkyl group or the like; R10 and R11 may be the same or different and are each a hydrogen atom, a C1-6 alkyl group, or the like; and R12 and R13 may be the same or different and are each a hydrogen atom, an alkyl group, or the like.
Facile synthesis of fluorinated 1-desazapurines
Iaroshenko, Viktor O.,Sevenard, Dmitri V.,Volochnyuk, Dmitriy M.,Wang, Yan,Martiloga, Alexander,Tolmachev, Andrei O.
experimental part, p. 1865 - 1875 (2009/12/30)
A preparative approach towards 1-desazapurines, starting from 4(5)-aminoimidazoles and polyfluoroalkyl-containing 1,3-CCC-biselectrophiles was developed. As a result, a set of fluorinated 1-desazapurines was synthesized. Additionally, a synthetic route to 1-desazapurines bearing a sugar-mimicking group is proposed. Georg Thieme Verlag Stuttgart.
Preparation of 9-substituted pyridine-stretched adenines and hypoxanthines
Crawford, Julia A.,Fraser, William,Ramsden, Christopher A.
experimental part, p. 1271 - 1278 (2009/12/07)
9-Methylsulfanyl pyridine-stretched adenine and hypoxanthine derivatives have been prepared via regioselective reaction of a 5-aminoimidazole with 2-(bis-methylsulfanylmethylene)malononitrile [(NC)2C=C(SMe) 2]. The 9-methylsulfanyl substituent can be replaced by sequential oxidation and substitution by nucleophiles including amines. Georg Thieme Verlag Stuttgart.
Novel imidazole compounds and use of these compounds for dyeing keratinous fibers
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, (2008/06/13)
The disclosure relates to novel imidazole compounds which can be useful as couplers for the oxidation dyeing of keratinous fibers. The present disclosure also relates to a dyeing composition for dyeing keratinous fibers comprising at least one oxidation base and at least one coupler of the imidazole type as disclosed herein, and the dyeing method using this composition.
SUBSTITUTED IMIDAZO-FUSED 5-MEMBERED RING HETEROCYCLES AND THEIR USE AS ANGIOTENSIN II ANTAGONISTS
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, (2008/06/13)
There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists. These compounds have the general formula: STR1
Preparation, Structure and Addition Reactions of 4- and 5-Aminoimidazoles
Al-Shaar, Adnan H. M.,Gilmour, David W.,Lythgoe, David J.,McClenaghan, Ian,Ramsden, Christopher A.
, p. 2779 - 2788 (2007/10/02)
Catalytic reduction of 5-nitroimidazoles 4 in dioxane solution gives 5-aminoimidazoles 2 in good yield.The derivatives 2d-f were isolated as stable, crystalline compounds which undergo slow decomposition on exposure to air.In a similar manner, solutions o