80927-46-4Relevant academic research and scientific papers
Basic Anion-Exchange Resin-Catalyzed Aldol Condensation of Aromatic Ketones with Aldehydes in Continuous Flow
Laroche, Benjamin,Saito, Yuki,Ishitani, Haruro,Kobayashi, Shū
supporting information, p. 961 - 967 (2019/05/02)
A general method for the aldol condensation of aromatic ketones with aldehydes was developed under continuous-flow conditions using a commercially available, strongly basic anion-exchange resin (A26) as catalyst. This procedure, in addition to exhibiting a wide substrate scope, promoted carbon-carbon bond formation under mild conditions using a quasi-stoichiometric ratio of starting reagents with good to excellent yields, thereby forming a limited amount of waste and allowing the process to be applied to sequential-flow systems. A proof of concept was developed in the first fully heterogeneously catalyzed two-step flow synthesis of donepezil, which is a blockbuster commercial anti-Alzheimer's drug.
Attempts toward synthesis of 2,6-Bis(2-furyl)-4-phenylpyrylium Tetrafluoroborate
Reichardt, Christian,Milart, Pjotr
, p. 401 - 402 (2007/10/02)
An improved synthesis of the 1,5-diketone 3 is reported.Ring closure of 3 with triphenylcarbenium tetrafluoroborate leads only to a mixture of the pyrylium salts 4 and 5.
THIAPYRYLIUM AND PYRYLIUM SALTS WITH FURYL SUBSTITUENTS
Kharchenko, V. G.,Burov, E. V.,Sedavkina, V. A.
, p. 1168 - 1170 (2007/10/02)
The possibility of obtaining pyrylium and thiapyrylium salts that contain acidophobic furyl substituents by the action of protic acids on the corresponding 1,5-diketones in acetic acid or methanol, depending on the position of the furan rings relative to
