83463-12-1

Basic information

• Product Name: 4-Phenylpyridine-2,6-dicarboxylic acid
• Synonyms: 4-Phenylpyridine-2,6-dicarboxylic acid
• CAS NO: 83463-12-1
• Molecular Formula: C₁₃H₉NO₄
• Molecular Weight: 243.21
• Mol File: 83463-12-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Phenylpyridine-2,6-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenylpyridine-2,6-dicarboxylic acid(83463-12-1)
• EPA Substance Registry System: 4-Phenylpyridine-2,6-dicarboxylic acid(83463-12-1)

Safety Data

• Hazardous Substances Data: 83463-12-1(Hazardous Substances Data)

Upstream product

• 3044-71-1 2,6-dimethyl-4-phenylpyridine 
• 117095-81-5 4-phenyl-2,6-pyridinedicarboxylic acid dimethyl ester 
• 3988-74-7 (E)-1-(furan-2-yl)-3-phenylprop-2-en-1-one 
• 162102-79-6 dimethyl 4-bromo-2,6-pyridinedicarboxylate 
• 19872-91-4 dimethyl 4-hydroxypyridine-2,6-dicarboxylate 
• 499-51-4 Chelidamic acid 
• 117095-82-6 4-phenyl-2,6-pyridinedicarboxylic acid diethyl ester 
• 5689-65-6 2,6-di(furan-2-yl)-4-phenylpyridine 
• 7732-18-5 water 
• 80927-46-4 1,5-Bis(2-furyl)-3-phenylpentan-1,5-dion 
• 138-60-3 chelidamic acid 
• 5371-70-0 dimethyl 4-chloro-2,6-pyridinedicarboxylate 
• 71022-75-8 4-chloropyridine-2,6-dicarbonyl dichloride 

Downstream Products

• 117095-81-5 4-phenyl-2,6-pyridinedicarboxylic acid dimethyl ester 
• 106023-86-3 C₁₃H₇Cl₂NO₂ 
• 117095-88-2 4-phenyl-2,6-pyrido-27-crown-9 
• 117095-84-8 4-phenyl-bis(2,6-bromomethyl)pyridine 
• 117095-83-7 2,6-bis(hydroxymethyl)-4-phenylpyridine 
• 939-23-1 p-phenylpyridine 

Relevant articles and documents

Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1

The efficacy of β-lactam antibiotics is threatened by the emergence and global spread of metallo-β-lactamase (MBL) mediated resistance, specifically New Delhi metallo-β-lactamase-1 (NDM-1). By utilization of fragment-based drug discovery (FBDD), a new class of inhibitors for NDM-1 and two related β-lactamases, IMP-1 and VIM-2, was identified. On the basis of 2,6-dipicolinic acid (DPA), several libraries were synthesized for structure-activity relationship (SAR) analysis. Inhibitor 36 (IC50 = 80 nM) was identified to be highly selective for MBLs when compared to other Zn(II) metalloenzymes. While DPA displayed a propensity to chelate metal ions from NDM-1, 36 formed a stable NDM-1:Zn(II):inhibitor ternary complex, as demonstrated by 1H NMR, electron paramagnetic resonance (EPR) spectroscopy, equilibrium dialysis, intrinsic tryptophan fluorescence emission, and UV-vis spectroscopy. When coadministered with 36 (at concentrations nontoxic to mammalian cells), the minimum inhibitory concentrations (MICs) of imipenem against clinical isolates of Eschericia coli and Klebsiella pneumoniae harboring NDM-1 were reduced to susceptible levels.

Ruthenium-catalyzed asymmetric epoxidation of olefins using H 2O2, part I: Synthesis of new chiral N,N,N,-tridentate pybox and pyboxazine ligands and their ruthenium complexes

The synthesis of chiral tridentate N,N,N-pyridine-2.6-bisoxazolines 3 (pyhox ligands) and N,N,N-pyridine-2.6-bisoxazines 4 (pyboxazine ligands) is described in detail. These novel ligands constitute a useful tool-box for the application in asymmetric catalysis. Compounds 3 and 4 are conveniently prepared by cyclization of enantiomerically pure α- or β-amino al cohols with dimethyl pyridine-2,6-dicarboximidate. The corresponding ruthenium complexes are efficient asymmetric epoxidation catalysts and have been prepared in good yield and fully char acterized by spectroscopic means. Four of these ruthenium complexes have been characterized by X-ray crystallography. For the first time the molecular structure of a pyboxazine complex (2,6-bis-[(4S)-4-phenyl-5,6- dihydro-4H-[1,3]oxazinyl]pyridine)(pyridine-2,6-dicarboxylate)ruthenium (S)-2aa, is presented.

Synthesis of 4-Arylpyridines

-