80929-63-1

Upstream product

• 288-32-4 1H-imidazole 
• 66125-08-4 3-bromo-6-methoxy-2,3-dihydro-4H-1-benzopyran-4-one 

Downstream Products

• 344573-06-4 3-(1H-imidazol-1-yl)-4-(2,6-dichlorobenzyloxy)-6-methoxy-2,3-dihydro-4H-1-benzopyran 

Relevant academic research and scientific papers

N-Imidazolyl derivatives containing naphthalene or indene nucleus

Compounds of the formula (I) STR1 wherein the symbol represents a single or a double bond; Z completes a single bond or is a --CH2 -- group; each of R1, R2, R3 and R4, which may be the same or different is (a) hydrogen; hydroxy; halogen; cyano; C1 -C6 alkyl; C1 -C6 alkoxy; a C2 -C4 acyl or C2 -C4 acylamino group; --SR', --N(R') (R"), --CH2 OR', --COR or --CH2 COR, wherein R is OR' or --N(R') (R") and each of R' and R", being the same or different, is hydrogen or C1 -C6 alkyl; or (b) one of R1, R2, R3 and R4 is 5- tetrazolyl or a group selected from --COCH2 OR', --CH=C(R')-COR and --X-C(R') (R")-COR, wherein R, R' and R" are as defined above, and X is --O--, --S--, or --NH--, and the others are as defined above under (a); one of R5 and R6 is hydrogen and the other is hydrogen, C1 -C6 alkyl, C3 -C6 cycloalkyl, or a phenyl or pyridyl ring, wherein the phenyl or pyridyl ring is unsubstituted or substituted by one to three substituents chosen from hydroxy and C1 -C4 alkoxy; or pharmaceutically acceptable salts thereof exhibit pharmaceutical activity as vasodilators or blood platelet aggregation inhibitors. Additionally, these compounds and their pharmaceutically acceptable salts are useful in the treatment of migraine, diabetic microangeopathy, rheumatoid arthritis, hypertension, peptic ulcers, osteoporosis, angina pectoris, atherosclerosis and dislipidaemies.

Imidazolyl Derivatives of The Chroman Ring. 1.

The synthesis of 2-(1H-imidazol-1-yl)-2,3-dihydro-2H-1-benzopyran-4-ones (I) through 3-bromo-2,3-dihydro-4H-1-benzopyran-4-ones or more conveniently through chroman ring closure from 2-(1H-imidazol-1-yl)-2'-hydroxy-acetophenones is described.The ring closure also works well for the pyrazolyl derivatives.Compounds I and the corresponding imidazolylchromanols, -chromenes, and -chromans derived from the former, were pharmacologically investigated.