80953-60-2

Upstream product

• 2899-60-7 Cbz-Gly-ONSuc 
• 4043-87-2 pipecolic Acid 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 32559-18-5 methyl piperidine-2-carboxylate hydrochloride 

Downstream Products

• 73269-83-7 {2-[2-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid benzyl ester 
• 80953-63-5 [2-(2-Methoxy-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of polycyclic aminal heterocycles via decarboxylative cyclisation of dipeptide derivatives

An oxidative-decarboxylative intramolecular cyclisation of dipeptide derivatives is reported. This transformation is promoted by phenyl iodine(iii) diacetate (PIDA) in combination with BF3·OEt2. The reaction gives access to a variety of valuable polycyclic N-heterocyclic scaffolds containing 5-, 6-, or 7-membered rings.

ANALOGS OF GLYCYL-PROLYL-GLUTAMATE

Embodiments of this invention include novel analogs of Glycyl-Prolyl-Glutamate (GPE) and compositions containing such analogs of GPE. Of these, certain analogs have modified proline residues. Other embodiments of this invention include uses of analogs of GPE to protect neural cells from degeneration and/or death in response to injury or disease. Disorders treatable with compounds and compositions of this invention include hypoxia/ischemia, toxic injury, and chronic neurodegenerative disorders including Parkinson''s disease.