80981-29-9Relevant articles and documents
Pyrimidine Derivatives and Related Compounds. Part 45. Synthesis of 4-Allophanoylpyrazoles via a Pyrimidine-to-pyrazole Ring Transformation
Hirota, Kosaku,Kitade, Yukio,Shimada, Kaoru,Senda, Shiego,Maki, Yoshifumi
, p. 1293 - 1298 (2007/10/02)
Reaction of the 5-formyluracil derivatives (1a-f) with hydrazines in the presence of acetic acid produced a ring contraction to give the corresponding 4-allophanoylpyrazoles (2a-h).Further treatment of these pyrazoles (2a-h) with sodium methoxide afforded methyl pyrazole-4-carboxylate (3a).Conceivable mechanisms for the present pyrimidine-to-pyrazole transformation were discussed.