7188-96-7

Usage

Methyl ester derivative

1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER is derived from pyrazole-4-carboxylic acid by attaching a methyl group to the carboxylic acid functional group.

Phenyl group attachment

The compound features a phenyl group (a carbon-based ring structure) attached to the 1-position of the pyrazole ring, which influences its chemical properties and reactivity.

Potential applications

1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER has potential uses in the fields of organic chemistry, medicinal chemistry, and pharmaceutical research.

Building block for synthesis

1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER can be used as a building block for the synthesis of various bioactive compounds and pharmaceutical drugs, making it a valuable component in the development of new therapeutic agents.

Reactivity and properties

The properties and reactivity of 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER make it a useful tool for creating new chemical entities with therapeutic potential, further expanding its applications in the field of chemistry and pharmaceuticals.

Upstream product

• 922-67-8 propynoic acid methyl ester 
• 100-63-0 phenylhydrazine 
• 622-11-7 α-nitroformaldehyde phenylhydrazone 
• 292638-85-8 acrylic acid methyl ester 
• 124-41-4 sodium methylate 
• 80981-29-9 1,3-dimethyluracil-5-carbaldehyde phenylhydrazone 

Downstream Products

• 70817-26-4 (1-phenyl-1H-pyrazol-4-yl)methanol 
• 1134-50-5 4-carboxy-1-phenylpyrazole 

Relevant academic research and scientific papers

Solvent-free and montmorillonite K10-catalyzed domino reactions for the synthesis of pyrazoles with alkynylester as a dual synthon

A highly regioselective, solvent-free and montmorillonite K10 clay-catalyzed domino process with an unprecedented ring-closing C-C bond-formation reaction is described for the synthesis of a new class of 1,3,4-trisubstituted and 1,4-disubstituted pyrazole

Process for preparing heterocycles

Process for the preparation of heterocycles by reacting 2-substituted acetals of malondialdehyde with a reactant selected from hydroxylamines and their salts, hydrazines and their salts, formamid, amidines and their salts, guanidines and their salts, aminoguanidines and their salts, nitroguanidine and their salts, O-alkyl-isoureas and their salts, O-cycloalkyl-isoureas and their salts, O-aralkyl-isoureas and their salts, O-aryl-isoureas and their salts, S-alkyl-isothioureas, S-cycloalkyl-isothioureas, S-aralkyl-isothioureas, S-arylisothioureas, S-alkyl-isothiouronium salts, S-cycloalkyl-isothiouronium salts, S-aralkyl-isothiouronium salts, S-aryl-isothiuronium salts, thiourea and urea.

1,3-Dipolar Cycloadditions, 87. Contributions to the Chemistry of N-Phenylnitrilimine

The N-phenyl derivative 7 is introduced as the first monosubstituted and interceptible nitrilimine whereas the cycloadditions of disubstituted representatives have been preparatively utilized in the past.Photolysis of 2-phenyltetrazole in the presence of methyl acrylate gives rise to methyl 1-phenyl-2-pyrazoline-5-carboxylate which on further irradiation suffers ring cleavage.The sodium salt of α-nitroformaldehyde phenylhydrazone (15) eliminates NaNO2 in refluxing acetonitrile whereby the intermediate 7 is accepted in situ by acrylic ester, styrene and norbornene.The interaction of methyl acrylate with the anionic precursor 15 furnishes further products.The formal dimer of 7, the 1,4-diphenyl-1,4-dihydro-1,2,4,5-tetrazine, is probably formed by reaction of 7 with 15.

Pyrimidine Derivatives and Related Compounds. Part 45. Synthesis of 4-Allophanoylpyrazoles via a Pyrimidine-to-pyrazole Ring Transformation

Reaction of the 5-formyluracil derivatives (1a-f) with hydrazines in the presence of acetic acid produced a ring contraction to give the corresponding 4-allophanoylpyrazoles (2a-h).Further treatment of these pyrazoles (2a-h) with sodium methoxide afforded methyl pyrazole-4-carboxylate (3a).Conceivable mechanisms for the present pyrimidine-to-pyrazole transformation were discussed.

A RING TRANSFORMATION OF URACIL INTO THE PYRAZOLE RING SYSTEM. REINVESTIGATION OF THE REACTION OF 5-FORMYLURACILS WITH HYDRAZINES

Cheng et al. reported that the reaction of 5-formyluracil (1a) with hydrazine hydrate in the presence of acetic acid gave 4-ureidomethylene-1H-5-pyrazolone (3).However, results of our reinvestigation revealed that the Cheng's compound (3) should be 4-urei