81016-75-3

Upstream product

• 31005-72-8 2,2-dimethylchroman-7-ol 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 127-08-2 potassium acetate 
• 91735-46-5 6-benzoyl-3,4-dihydro-7-hydroxy-2,2-dimethyl-2H-1-benzopyran 
• 78-79-5 isoprene 
• 115-18-4 2-methyl-3-buten-2-ol 
• 108-46-3 recorcinol 
• 91735-50-1 6-benzoyl-3,4-dihydroxy-7-hydroxy-8-iodo-2,2-dimethyl-2H-1-benzopyran 
• 33427-62-2 2,4-dihydroxy-3-iodobenzophenone 

Downstream Products

• 84531-54-4 3-phenyl-7,7-dimethyl-6,7-dihydro-7H-furo<3,2-g><1>benzopyran-2-carboxylic acid 
• 84531-49-7 3-bromo-4-phenyl-6,7-dihydroxanthyletin 
• 74794-35-7 2,2-dimethyl-6-phenyl-2H,8H-benzo<1,2-b:5,4-b'>dipyran-8-one 

Relevant academic research and scientific papers

Pancreatic α-Amylase inhibition and free radical scavenging activity of substituted pyranochromenone derivatives

Pyranochromenone derivatives 3a-d, 6a-j and 2H-chromenones 8a-b were synthesized and screened for their in vitro α-Amylase inhibitory and ABTS?+ [2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] free radical scavenging activities. Compounds 3a, 3c, and 6d displayed dual function of ABTS?+ radical scavenging as well as α-Amylase inhibition. Compound 6h was found to be most potent α-Amylase inhibitor in present series of compounds. Docking studies suggest that these compounds occupy active site of the human pancreatic α-Amylase similar to that of acarbose which inhibits enzyme by hydrophobic interactions. These compounds have potential to be developed as therapeutics targeted against diet-induced hyperglycemia in diabetes. Graphical abstract: Series of pyranochromenone derivatives 3a-d, 6a-j, and 8a-b were synthesized, among these compound 6h shown potent intestinal α-Amylase inhibitory activity. Compounds 3a, 3c, and 6d were shown dual properties such as α-Amylase inhibitory and antioxidant activities. These derivatives may serve as a model compounds for design and development of therapeutics based agents.[Figure not available: see fulltext.]

An Improved Synthesis of Benzoyl-chromans and Chromenes

Direct nuclear isoprenylation of polyhydroxybenzophenones with 2-methylbut-1,3-diene (isoprene) in the presence of orthophosphoric acid results exclusively in the formation of benzoylchromans in good yields.These benzoylchromans on dehydrogenation with DD

Synthesis of Some 6,7-Dihydroxanthyletins and Their Conversion into Dihydrofurobenzopyran-2-carboxylic Acids

Pechmann condensation of 7-hydroxy-2,2-dimethylchromans (I) with ethyl acetoacetate and ethyl benzoylacetate, furnishes 4-methyl- and 4-phenyl-6,7-dihydroxanthyletins (II and III) respectively in excellent yield.Brominations of these compounds gives the c