81038-81-5Relevant academic research and scientific papers
Selective synthesis of functionalized quinazolinone derivatives via biocatalysis
Gong, Bozhen,Lan, Jin,Le, Zhanggao,Li, Hongxia,Meng, Jia,Xie, Zongbo
, (2020/11/02)
A novel and efficient biocatalyzed methodology for the construction of functionalized quinazolinone derivatives via tandem / hydrolysis / decarboxylation / cyclization and transesterification reactions has been developed that works with a variety of 2-aminobenzamide and β-dicarbonyl compounds. This method requires mild conditions, and has demonstrated high catalytic activity, excellent yields, excellent chemoselectivity, and a broad substrate scope. Additionally, biocatalyzed decarboxylation does not require high temperatures or light activation, giving it a substantial advantage over alternative techniques. Most importantly, it offers a new example for the exploration of simple, convenient, and environmentally friendly synthetic routes utilizing enzymes in organic chemistry.
