81060-37-9

Upstream product

• 75-25-2 Bromoform 
• 2043-61-0 cyclohexanecarbaldehyde 
• 74-95-3 1,1-dibromomethane 

Downstream Products

• 112741-25-0 2-Bromo-1-cyclohexyl-3-hydroxy-3-[(1S,2R,3aS,6aS)-5-[2-methoxy-eth-(E)-ylidene]-2-(tetrahydro-pyran-2-yloxy)-octahydro-pentalen-1-yl]-propan-1-one 
• 120294-28-2 (Z)-2-Bromo-1-cyclohexyl-3-[(1S,2R,3aS,6aS)-5-[2-methoxy-eth-(E)-ylidene]-2-(tetrahydro-pyran-2-yloxy)-octahydro-pentalen-1-yl]-propenone 
• 112741-38-5 (E)-1-Cyclohexyl-3-[(1R,2R,3aS,6aS)-5-[2-methoxy-eth-(E)-ylidene]-2-(tetrahydro-pyran-2-yloxy)-octahydro-pentalen-1-yl]-propenone 
• 112741-18-1 2,2-dibromo-1-cyclohexyl-1-ethanone 
• 1204979-80-5 (2-bromovinyl)cyclohexane 

Relevant academic research and scientific papers

Bromoform activation. TiCl4-Mg-promoted CHBr2 - and CBr3- transfer to a variety of aldehydes and ketones

TiCl4-Mg can mediate addition of CHBr3 to a variety of aldehydes and ketones to form dibromomethyl carbinols and also be used to effect CBr3 transfer to carbonyl groups to form tribromomethyl carbinols. The successful application of TiCl4-Mg-promoted coupling of CHBr3 with various carbonyl compounds, especially in the case of highly enolizable ketones such as 2-indanone and β-tetralone, highlights the extraordinary reactivity and selectivity and the weakly basic nature of this system.

A New Method for the Introduction of Carbon-Carbon Triple Bond at C-13 in PG Synthesis. A Stereocontrolled Synthesis of ZK 96 480

ZK 96 480, a chemically and metabolically stable prostacyclin analogue, has been synthesized from the Corey lactone in a stereocontrolled manner by a route utilizing a newlyeveloped method for introduction of the carbon-carbon triple bond at C-13 (PG numb

A PREPARATION OF BROMOOLEFINS FROM CARBONYL COMPOUNDS

A variety of 1-bromoalkenes are prepared by addition of dibromomethyllithium to ketones and aldehydes followed by reductive elimination with zinc-acetic acid.The product E/Z ratios were determined, and halogen-lithium exchange with t-butyllithium was examined.