81066-66-2Relevant academic research and scientific papers
2-pyridinylguanidine urokinase inhibitors
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, (2008/06/13)
Compounds of formula (I): or a pharmaceutically acceptable salt thereof, or solvate of either entity, wherein R4is a guanidinyl moiety and the other substituents are as defined in the text, are urokinase inhibitors.
Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-substituted-5-halo-2-pyridinyl)guanidines
Barber, Christopher G.,Dickinson, Roger P.
, p. 185 - 187 (2007/10/03)
Based on previous modeling predictions, a series of (3-substituted-5-chloro-2-pyridinyl)guanidines have been designed with good potency and selectivity for urokinase-type plasminogen activator (uPA). Compound 36 has a Ki of 0.17 μM and greater than 300-fold selectivity with respect to tPA and plasmin.
