40966-87-8

Basic information

• Product Name: 2-Amino-3-hydroxy-5-chloropyridine
• Synonyms: 2-Amino-3-hydroxy-5-chloropyridine;2-amino-5-chloropyridin-3-ol;2-anino-5-chloropyridin-3-ol;2-Amino-5-chloro-3-hydroxypyridine
• CAS NO: 40966-87-8
• Molecular Formula: C₅H₅ClN₂O
• Molecular Weight: 144.56
• Mol File: 40966-87-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 198-201℃
• Boiling Point: 383.7 °C at 760 mmHg
• Flash Point: 185.9 °C
• Appearance: /
• Density: 1.516
• Vapor Pressure: 1.95E-06mmHg at 25°C
• Refractive Index: 1.664
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.48±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-hydroxy-5-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-hydroxy-5-chloropyridine(40966-87-8)
• EPA Substance Registry System: 2-Amino-3-hydroxy-5-chloropyridine(40966-87-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37
• Hazardous Substances Data: 40966-87-8(Hazardous Substances Data)

Usage

General Description

2-Amino-3-hydroxy-5-chloropyridine is a chemical compound with the molecular formula C5H5ClN2O and a molecular weight of 144.56 g/mol. It is a derivative of pyridine and contains an amino group, a hydroxyl group, and a chlorine atom. 2-Amino-3-hydroxy-5-chloropyridine has potential applications in the pharmaceutical and agrochemical industries as a building block for the synthesis of various compounds. It may also have biological activity and be used as a reagent in chemical reactions. 2-Amino-3-hydroxy-5-chloropyridine should be handled and used with proper safety precautions due to its potential hazards and toxicity.

InChI:InChI=1/C5H5ClN2O/c6-3-1-4(9)5(7)8-2-3/h1-2,9H,(H2,7,8)

Upstream product

• 4214-74-8 3,5-dichloropyridin-2-amine 
• 12775-96-1 copper 
• 874-24-8 3-hydroxypyridine-2-carboxylic acid 
• 60832-72-6 2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one 
• 35570-68-4 6-chlorooxazole[4,5-b]pyridine-2(3H)-one 
• 26163-03-1 2-amino-3-bromo-5-chloropyridine 
• 16867-03-1 2-amino-3-hydroxypyridine 

Downstream Products

• 35570-68-4 6-chlorooxazole[4,5-b]pyridine-2(3H)-one 
• 1609082-30-5 ethyl 6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylate 
• 1609082-31-6 6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid 
• 1609082-29-2 5-chloro-3-[(2,6-difluorobenzyl)oxy]pyridine-2-amine 
• 301542-58-5 2-(2-amino-5-chloro-pyridin-3-yloxy)-N-benzyl-acetamide 
• 81066-66-2 3-(Benzyloxy)-5-chloro-2-pyridinamine 

Relevant articles and documents

-

-

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

2-amino-3-hydroxy-5-chloro-pyridine synthesis method

The invention belongs to the field of organic synthesis and particularly relates to a synthesis method for 2-amino-3-hydroxyl-5-chloropyridine. The synthesis method for the 2-amino-3-hydroxyl-5-chloropyridine comprises the following steps: reacting oxazole[4,5-b]pyridine-2(3H)ketone and NCS (N-chlorosuccinimide) in a suitable solvent at a suitable temperature to generate 6-chlorooxazole[4,5-b]pyridine-2(3H)ketone; and then carrying out alkalization hydrolysis to generate the 2-amino-3-hydroxyl-5-chloropyridine. The synthesis method has the beneficial effects that the raw materials are easily available and are convenient to transport and store as being solids; meanwhile, in the reaction, heavy metal and corrosive gas are not used, the reaction is moderate, special requirements on reaction equipment do not exist and common corrosion-resisting equipment can be used for producing; furthermore, the reaction time is moderate, the reaction is easy to control, the post-treatment is simple, the product purity is high, the production cost is low and the synthesis method is easy to popularize and apply.