40966-87-8

Basic information

• Product Name: 2-Amino-3-hydroxy-5-chloropyridine
• Synonyms: 2-Amino-3-hydroxy-5-chloropyridine;2-amino-5-chloropyridin-3-ol;2-anino-5-chloropyridin-3-ol;2-Amino-5-chloro-3-hydroxypyridine
• CAS NO: 40966-87-8
• Molecular Formula: C₅H₅ClN₂O
• Molecular Weight: 144.56
• Mol File: 40966-87-8.mol

Chemical Properties

• Melting Point: 198-201℃
• Boiling Point: 383.7 °C at 760 mmHg
• Flash Point: 185.9 °C
• Appearance: /
• Density: 1.516
• Vapor Pressure: 1.95E-06mmHg at 25°C
• Refractive Index: 1.664
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.48±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-hydroxy-5-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-hydroxy-5-chloropyridine(40966-87-8)
• EPA Substance Registry System: 2-Amino-3-hydroxy-5-chloropyridine(40966-87-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37
• Hazardous Substances Data: 40966-87-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-3-hydroxy-5-chloropyridine is used as a building block for the synthesis of pharmaceutical compounds due to its unique chemical structure and functional groups, which can be utilized in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Amino-3-hydroxy-5-chloropyridine is employed as a precursor in the synthesis of various agrochemicals, contributing to the creation of effective pesticides and other related products.
Used as a Reagent in Chemical Reactions:
2-Amino-3-hydroxy-5-chloropyridine is used as a reagent in chemical reactions, taking advantage of its reactive functional groups to facilitate specific transformations or syntheses in organic chemistry.
Safety Precautions:
Due to its potential hazards and toxicity, 2-Amino-3-hydroxy-5-chloropyridine should be handled and used with appropriate safety measures, including personal protective equipment and proper disposal methods, to minimize risks to human health and the environment.

InChI:InChI=1/C5H5ClN2O/c6-3-1-4(9)5(7)8-2-3/h1-2,9H,(H2,7,8)

Upstream product

• 12775-96-1 copper 
• 26163-03-1 2-amino-3-bromo-5-chloropyridine 
• 4214-74-8 3,5-dichloropyridin-2-amine 
• 874-24-8 3-hydroxypyridine-2-carboxylic acid 
• 60832-72-6 2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one 
• 35570-68-4 6-chlorooxazole[4,5-b]pyridine-2(3H)-one 
• 16867-03-1 2-amino-3-hydroxypyridine 

Downstream Products

• 81066-66-2 3-(Benzyloxy)-5-chloro-2-pyridinamine 
• 35570-68-4 6-chlorooxazole[4,5-b]pyridine-2(3H)-one 
• 1609082-29-2 5-chloro-3-[(2,6-difluorobenzyl)oxy]pyridine-2-amine 
• 1609082-31-6 6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid 
• 1609082-30-5 ethyl 6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylate 
• 301542-87-0 C₂₅H₃₂ClN₅O₆ 
• 301542-84-7 C₂₃H₂₉ClN₄O₅ 

Relevant articles and documents

HETEROARYL COMPOUNDS AS KINASE INHIBITOR

Provided herein are heteroaryl compounds of formula (I) having activity on a receptor protein tyrosine kinase, wherein R 1, R 2, R 3, A, Q, Z, X and W are set forth in the description, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof.

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

ARYL- AND HETARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDES AND USE THEREOF

The present application relates to novel aryl- and hetaryl-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

2-amino-3-hydroxy-5-chloro-pyridine synthesis method

The invention belongs to the field of organic synthesis and particularly relates to a synthesis method for 2-amino-3-hydroxyl-5-chloropyridine. The synthesis method for the 2-amino-3-hydroxyl-5-chloropyridine comprises the following steps: reacting oxazole[4,5-b]pyridine-2(3H)ketone and NCS (N-chlorosuccinimide) in a suitable solvent at a suitable temperature to generate 6-chlorooxazole[4,5-b]pyridine-2(3H)ketone; and then carrying out alkalization hydrolysis to generate the 2-amino-3-hydroxyl-5-chloropyridine. The synthesis method has the beneficial effects that the raw materials are easily available and are convenient to transport and store as being solids; meanwhile, in the reaction, heavy metal and corrosive gas are not used, the reaction is moderate, special requirements on reaction equipment do not exist and common corrosion-resisting equipment can be used for producing; furthermore, the reaction time is moderate, the reaction is easy to control, the post-treatment is simple, the product purity is high, the production cost is low and the synthesis method is easy to popularize and apply.

Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use

The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

Process for the production of 2-amino-3-hydroxypyridine derivatives

2-Amino-3-hydroxy-5-chloropyridine and 2-amino-3-hydroxy-5-bromopyridine are produced by selective hydrolysis of corresponding 2-amino-3,5-dihalopyridines.

CNS active compounds

Compounds of the formula STR1 wherein R may be hydrogen or a straight or branched chain alkyl radical of from 1 to 10 carbon atoms, aryl of from 6 to 10 carbon atoms, or aralkyl of from 7 to 10 carbon atoms; Y may be hydrogen, alkyl of from 1 to 4 carbons, CF3, F, Cl, or Br; and Z may be hydrogen or as defined hereinafter. These compounds are useful as central nervous system stimulants or more specifically in enhancing performance or as mood elevators.