81088-41-7

Upstream product

• 74-89-5 methylamine 
• 136743-94-7 1-Carboxymethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-77-6 1-tert-Butoxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-59-4 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione 
• 67467-27-0 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid 
• 3320-83-0 o-chlorophenyl isocyanate 

Relevant academic research and scientific papers

Studies on hypotensive agents. Synthesis of 1-substituted 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinediones

3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinedione was newly prepared. 1-Hydrogen atoms of the compound were variously substituted in order to test for their hypotensive activities on relaxing effects of the blood vessels. The compounds with 2-(1-pyrrolidinyl ethyl, 2-(1-piperidinyl)ethyl, 3-(dimethylamino)propyl, and 3-(N-benzyl-N-methylamino)propyl moieties showed significant activity. The 2-(1-piperidinyl)ethyl compound possessed activity approximately 23 times more potent than papaverine, however, it was less potent than cinnarizine.