811-96-1Relevant academic research and scientific papers
N-HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR THE TREATMENT OF PARASITIC DISEASES
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Page/Page column 90, (2012/04/17)
This invention relates to certain N-heteroaryl compounds that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of the N-heteroaryl compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.
Time Resolved Studies of Intermediate Products in the Oxidation of HCFC 141b (CFCl2CH3)and HCFC (CF2ClCH3)
Moers,Hoffmann,Malms,Zellner
, p. 540 - 552 (2007/10/03)
The oxiueauve degradation of HCFC 14Sb (CFCl2CH3) and HCFC 142b (CF2C1CH3) in the presence of NO at T = 293 K and p = 50 mbar has been studied using laser pulse initiation combined with cw laser long path absorption/UF for the detection of OH and NO2. The absolute yield and temporal behaviour of these products have been found to be sensitive indicators for the reaction behaviour of the alkoxy radicals CFCl2CH2O and CF2ClCH2O, respectively. The rate coefficients for the reactions of the alkoxy radicals with O2 were determined to be k(CFCl2CH2O + O2-CFCl2CHO + HO2) = (2.0±1.0)× 10-15 cm3/s and k(CF2ClCH2O + O2→CF2CiCHO + HO2) = (2.5±1.5)× 10-15 cm3/s. Upper limits for the rate coefficients for unimolecular decomposition of the alkoxy radicals by C-C-bond fission of k(CFCl2CH2O + M→CFCl2 + CH2O-rM)≤ 1.0×103 s-1 and k(CF2ClCH2O + M→CF2Cl + CH2OJ-M)≤1.5×103s-1 were derived. We conclude from these data that CFCl2CHO and CF2ClCHO will be formed as the dominant primary carbonyl products in the oxidation of HCFC 141 b and 142b throughout the troposphere. Moreover, the rate coefficients for the reactions of the HCFCs with OH radicals at T = 293 K have been measured. The values k(CFCl2CH3 +OH→CFCl2CH2 + H2O) = (4.6 ±0.8)×10-15 cm3/s and k(CF2ClCH3 + OH→CF2ClCH2 + H2O) = (2.6±0.4)× 10-15cm3/s were obtained. VCH Verlagsgesel/schaft mbH, 1996.
