81135-34-4 Usage
General Description
L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-alanyl]-N-methyl-, phenylmethyl ester, also known as Boc-Leu-Ala-NHMe, is a chemical compound used in various biochemical and pharmaceutical applications. It is a derivative of L-leucine, an essential amino acid that plays a key role in protein synthesis and muscle repair. The compound is often used in peptide synthesis as a building block for creating larger peptide chains. Boc-Leu-Ala-NHMe is also used as a substrate for proteases, enzymes that break down proteins, in research and drug development. Additionally, this compound has potential therapeutic applications due to its ability to modulate protein function and cellular processes.
Check Digit Verification of cas no
The CAS Registry Mumber 81135-34-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,1,3 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 81135-34:
(7*8)+(6*1)+(5*1)+(4*3)+(3*5)+(2*3)+(1*4)=104
104 % 10 = 4
So 81135-34-4 is a valid CAS Registry Number.
81135-34-4Relevant articles and documents
Total synthesis of cyclosporine: Access to N-methylated peptides via lsonitrile coupling reactions
Wu, Xiangyang,Stockdill, Jennifer L.,Wang, Ping,Danishefsky, Samuel J.
supporting information; experimental part, p. 4098 - 4100 (2010/05/15)
Recent developments in the use of isonitriles to furnish secondary and tertiary amide bond formations have been applied to a novel total synthesis of the important cyclic polypeptide cyclosporine A. Specifically, the disclosed synthetic route demonstrates the utility of microwave-mediated carboxylic acid isonitrile couplings, thioacid isonitrile couplings at ambient temperature, and isonitrile-mediated couplings of carboxylic acids and thioacids with amines to form challenging amide bonds. Copyright
Synthesis of cyclosporine. Part II. Synthesis of Boc-D-Ala-MeLeu-MeLeu-MeVal-OH, a part of the peptide sequence of cyclosporine, by different strategic ways and synthesis of its isomers Boc-D-Ala-MeLeu-D-MeLeu-MeVal-OH, Boc-D-Ala-Meleu-D-MeLeu-D-MeVal-OH,
Wenger
, p. 2672 - 2702 (2007/10/02)
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