81135-34-4 Usage
Uses
Used in Peptide Synthesis:
Boc-Leu-Ala-NHMe is utilized as a building block in peptide synthesis, allowing for the assembly of larger peptide chains. Its incorporation into peptides can influence their structure, stability, and biological activity.
Used in Research and Drug Development:
As a substrate for proteases, Boc-Leu-Ala-NHMe plays a significant role in research and drug development. It aids in understanding the mechanisms of proteolysis and the development of inhibitors or activators of protease activity, which can have therapeutic implications.
Used in Therapeutic Applications:
Boc-Leu-Ala-NHMe has potential therapeutic applications due to its ability to modulate protein function and cellular processes. Its effects on protein-protein interactions and enzymatic activities can be harnessed for the treatment of various diseases and conditions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Boc-Leu-Ala-NHMe is used as a key component in the development of drugs targeting specific proteases or protein functions. Its incorporation into drug candidates can enhance their efficacy and selectivity.
Used in Biochemical Research:
Boc-Leu-Ala-NHMe is employed in biochemical research to study the properties and functions of proteins and peptides. It can be used to probe the interactions between proteins and other biomolecules, providing insights into their mechanisms of action.
Check Digit Verification of cas no
The CAS Registry Mumber 81135-34-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,1,3 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 81135-34:
(7*8)+(6*1)+(5*1)+(4*3)+(3*5)+(2*3)+(1*4)=104
104 % 10 = 4
So 81135-34-4 is a valid CAS Registry Number.
81135-34-4Relevant academic research and scientific papers
Total synthesis of cyclosporine: Access to N-methylated peptides via lsonitrile coupling reactions
Wu, Xiangyang,Stockdill, Jennifer L.,Wang, Ping,Danishefsky, Samuel J.
supporting information; experimental part, p. 4098 - 4100 (2010/05/15)
Recent developments in the use of isonitriles to furnish secondary and tertiary amide bond formations have been applied to a novel total synthesis of the important cyclic polypeptide cyclosporine A. Specifically, the disclosed synthetic route demonstrates the utility of microwave-mediated carboxylic acid isonitrile couplings, thioacid isonitrile couplings at ambient temperature, and isonitrile-mediated couplings of carboxylic acids and thioacids with amines to form challenging amide bonds. Copyright
Amino Acids and Peptides, 63. - Peptide Synthesis via N- or O-Activation of Amino Acids with 1,2-Dihydro-4,6-dimethyl-2-thioxo-3-pyridinecarbonitrile. - Synthesis of the 8-11 Tetrapeptide Sequence of Cyclosporin
Schmidt, Ulrich,Potzolli, Bernd
, p. 935 - 942 (2007/10/02)
Peptides and N-methyl peptides have been prepared in high yields and nearly free of racemisation via N-activation (Scheme 1) or O-activation (Scheme 2) of N-acylamino acids and N-acyl-N-methylamino acids, respectively, by 1,2-dihydro-4,6-dimethyl-2-thioxo
