811467-26-2

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 39910-24-2 ethyl-3-hydroxy-2-diazo-3-(4-methoxyphenyl)-propanoate 
• 757227-80-8 3-chloro-3-(4-methoxy-phenyl)-2-oxo-propionic acid ethyl ester 

Downstream Products

• 1354789-96-0 (R)-ethyl 2-hydroxy-2-((R)-hydroxy(4-methoxyphenyl)methyl)pent-4-enoate 
• 757227-94-4 2-chloro-3-[5-(4-methoxy-phenyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-oxirane-2-carboxylic acid methyl ester 
• 757227-88-6 5-(4-methoxy-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester 
• 253350-07-1 ethyl 2,3-dihydroxy-3-(4-methoxyphenyl)propionate 

Relevant academic research and scientific papers

Novel synthesis of 4-chloro-3-hydroxy-2-pyrone by the reaction of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride

Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields. Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields.

Stereoselective reduction of β-hydroxy α-ketoesters: A concise synthesis of anti-α,β-dihydroxy esters

A new synthetic route to anti-α,β-dihydroxy esters has been developed. The new method consists of three steps starting from an aldehyde: the nucleophilic condensation with ethyl diazoacetate, oxidation with dimethyldioxirane, and stereoselective reduction with NaBH4.