81148-82-5

Basic information

• Product Name: 5-acetoxy-7,4′-dimethoxyflavanone
• Synonyms: 5-acetoxy-7,4′-dimethoxyflavanone
• CAS NO: 81148-82-5
• Molecular Weight: 342.348
• Mol File: 81148-82-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-acetoxy-7,4′-dimethoxyflavanone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-acetoxy-7,4′-dimethoxyflavanone(81148-82-5)
• EPA Substance Registry System: 5-acetoxy-7,4′-dimethoxyflavanone(81148-82-5)

Safety Data

• Hazardous Substances Data: 81148-82-5(Hazardous Substances Data)

Upstream product

• 3420-72-2 flavokawain A 
• 123-11-5 4-methoxy-benzaldehyde 
• 29424-96-2 naringenin-4',7-dimethyl ether 
• 75-36-5 acetyl chloride 
• 66074-95-1 4',5,7-trimethoxyflavanone 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Downstream Products

• 221257-06-3 7,4'-di-O-methylapigenin 5-O-1-β-xylopyranosyl(1->6)-β-glucopyranoside 

Relevant articles and documents

Total synthesis of agalloside, isolated from: Aquilaria agallocha, by the 5-O-glycosylation of flavan

Agalloside (1) is a neural stem cell differentiation activator isolated from Aquilaria agallocha by our group using Hes1 immobilized beads. We conducted the first total synthesis of agalloside (1) via the 5-O-glycosylation of flavan 25 using glycosyl fluoride 20 in the presence of BF3·Et2O. Subsequent oxidation with DDQ to flavanone 2 and deprotection successively provided agalloside (1). This synthetic strategy holds promise for use in the synthesis of 5-O-glycosylated flavonoids. The synthesized agalloside (1) accelerated neural stem cell differentiation, which is a result comparable to that for the naturally occurring compound 1.