811788-13-3Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of conformationally constrained cis-amide HSP90 inhibitors
Duerfeldt, Adam S.,Brandt, Gary E. L.,Blagg, Brian S.J.
supporting information; experimental part, p. 2353 - 2356 (2009/09/30)
Conformationally constrained cis-amide chimeric inhibitors of Hsp90 have been synthesized and evaluated for their Hsp90 inhibitory activity. These new compounds exhibited Hsp90 ATPase inhibition and induced Hsp90-dependent client protein degradation in a
Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin
Hadden, M. Kyle,Blagg, Brian S. J.
scheme or table, p. 4697 - 4704 (2009/10/17)
(Chemical Equation Presented) Previously, we reported the Hsp90 inhibitory activity of radamide, an open chain amide chimera of geldanamycin and radicicol. Attempts to further expand upon structure-activity relationships for this class of Hsp90 inhibitors
Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide
Clevenger, Randell C.,Blagg, Brian S. J.
, p. 4459 - 4462 (2007/10/03)
(Chemical equation presented) A chimera composed of the natural products radicicol and geldanamycin has been prepared through an amide linkage connecting the resorcinol moiety of radicicol to the quinone ring of geldanamycin. The inhibitory activity of th
