81189-93-7Relevant academic research and scientific papers
A new method for the synthesis of antihypercholesterolemic agent simvastatin
Dabak, Kadir,Adiyaman, Mustafa
, p. 673 - 677 (2003)
A new synthetic method for the preparation of the cholesterol-lowering drug simvastatin from the naturally occurring lovastatin is reported. The synthesis employs first the protection of the OH group of lovastatin (1) and then the protection of the lactone C=O group to prevent enolization via conversion to the orthoesters 4a and 4b. Alkylation of the 2-methylbutyrate side chain is then successfully achieved. Removal of the protecting groups affords antihypercholesterolemic agent simvastatin (2).
Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species
Lin, Ruo-Kai,Lin, Yuh-Feng,Hsu, Ming-Jen,Hsieh, Chang-Lin,Wang, Chen-Yu,Huang, Chih-Chiang,Huang, Wei-Jan
supporting information, p. 5528 - 5533 (2016/11/09)
Some hydroxamate compounds induce cancer cell death by intracellular reactive oxygen species (ROS). This study introduced the hydroxamate core into lovastatin, a fungus metabolite clinically used for the treatment of hypercholesterolemia. The resulting co
