81189-93-7Relevant articles and documents
A new method for the synthesis of antihypercholesterolemic agent simvastatin
Dabak, Kadir,Adiyaman, Mustafa
, p. 673 - 677 (2003)
A new synthetic method for the preparation of the cholesterol-lowering drug simvastatin from the naturally occurring lovastatin is reported. The synthesis employs first the protection of the OH group of lovastatin (1) and then the protection of the lactone C=O group to prevent enolization via conversion to the orthoesters 4a and 4b. Alkylation of the 2-methylbutyrate side chain is then successfully achieved. Removal of the protecting groups affords antihypercholesterolemic agent simvastatin (2).