81224-16-0

Basic information

• Product Name: 7-BROMO-4-METHOXYINDOLE
• Synonyms: 7-BROMO-4-METHOXYINDOLE;1H-Indole, 7-broMo-4-Methoxy-;bromo-7 methoxy-4 indole
• CAS NO: 81224-16-0
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.07
• Mol File: 81224-16-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 356.5 °C at 760 mmHg
• Flash Point: 169.4 °C
• Appearance: /
• Density: 1.591 g/cm³
• Vapor Pressure: 5.98E-05mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-BROMO-4-METHOXYINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-4-METHOXYINDOLE(81224-16-0)
• EPA Substance Registry System: 7-BROMO-4-METHOXYINDOLE(81224-16-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 81224-16-0(Hazardous Substances Data)

Usage

General Description

7-Bromo-4-methoxyindole is a synthetic compound identified by its unique molecular structure, with formula C9H8BrNO. Classified as part of the indoles group, it's a derivative of indole, which is a naturally occurring compound found in many plants and animals. It features a fused six membered benzene ring and a five membered nitrogen-containing pyrrole ring. Key components include bromine, and a methoxy group. This chemical compound is commonly utilized as a reactant or intermediate substance in the field of organic synthesis. Its specific properties have not been extensively studied hence toxicity and possible usage in medicinal applications are not yet fully understood.

InChI:InChI=1/C9H8BrNO/c1-12-8-3-2-7(10)9-6(8)4-5-11-9/h2-5,11H,1H3

Upstream product

• 59557-92-5 2-bromo-5-methoxyaniline 
• 107-14-2 chloroacetonitrile 
• 107-06-2 1,2-dichloro-ethane 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 81224-45-5 (Z)-2-Azido-3-(5-bromo-2-methoxy-phenyl)-acrylic acid methyl ester 
• 81224-14-8 bromo-7 methoxy-4 indolecarboxylate-2 de methyle 
• 5344-78-5 4-bromo-3-nitroanizole 
• 1826-67-1 vinyl magnesium bromide 
• 81224-15-9 acide bromo-7 methoxy-4 indolecarboxylique-2 

Downstream Products

• 1377584-52-5 C₃₂H₃₄N₄O₇ 
• 313335-01-2 C₂₂H₂₀BrN₃O₄ 
• 292636-19-2 N-(3-chloro-4-methoxy-1H-indol-7-yl)-4-nitro-benzenesulfonamide 
• 292636-25-0 N-(4-methoxy-1H-indol-7-yl)-4-nitro-benzenesulfonamide 

Relevant articles and documents

Field-based affinity optimization of a novel azabicyclohexane scaffold HIV-1 entry inhibitor

Small-molecule HIV-1 entry inhibitors are an extremely attractive therapeutic modality. We have previously demonstrated that the entry inhibitor class can be optimized by using computational means to identify and extend the chemotypes available. Here we demonstrate unique and differential effects of previously published antiviral compounds on the gross structure of the HIV-1 Env complex, with an azabicyclohexane scaffolded inhibitor having a positive effect on glycoprotein thermostability. We demonstrate that modification of the methyltriazole-azaindole headgroup of these entry inhibitors directly effects the potency of the compounds, and substitution of the methyltriazole with an amine-oxadiazole increases the affinity of the compound 1000-fold over parental by improving the on-rate kinetic parameter. These findings support the continuing exploration of compounds that shift the conformational equilibrium of HIV-1 Env as a novel strategy to improve future inhibitor and vaccine design efforts.

Methods and compounds for treating proliferative diseases

The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).

Synthese de derives indoliques substitues in 7

The synthesis and some aspects of the chemical reactivity of 7-acetyl, 7-benzoyl and 7-bromoindoles are described.