81224-16-0

Usage

Uses

Used in Organic Synthesis:
7-Bromo-4-methoxyindole is used as a reactant or intermediate substance for various organic synthesis processes. Its unique molecular structure, which includes a bromine atom and a methoxy group, allows for its use in the creation of complex organic molecules.
Used in Research and Development:
Due to its classification as an indole derivative, 7-Bromo-4-methoxyindole is used in research settings to study the properties and potential applications of indole-based compounds. This can include exploring its reactivity, stability, and possible interactions with other molecules, which may lead to new discoveries in the field of organic chemistry.
Potential Use in Medicinal Applications:
While not yet fully understood, the unique structure of 7-Bromo-4-methoxyindole suggests that it may have potential applications in medicinal chemistry. Further research is needed to determine its toxicity and possible uses in the development of new drugs or therapeutic agents.

InChI:InChI=1/C9H8BrNO/c1-12-8-3-2-7(10)9-6(8)4-5-11-9/h2-5,11H,1H3

Upstream product

• 81224-15-9 acide bromo-7 methoxy-4 indolecarboxylique-2 
• 59557-92-5 2-bromo-5-methoxyaniline 
• 107-14-2 chloroacetonitrile 
• 107-06-2 1,2-dichloro-ethane 
• 81224-45-5 (Z)-2-Azido-3-(5-bromo-2-methoxy-phenyl)-acrylic acid methyl ester 
• 5344-78-5 4-bromo-3-nitroanizole 
• 1826-67-1 vinyl magnesium bromide 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 81224-14-8 bromo-7 methoxy-4 indolecarboxylate-2 de methyle 

Downstream Products

• 1377584-52-5 C₃₂H₃₄N₄O₇ 
• 313335-01-2 C₂₂H₂₀BrN₃O₄ 
• 292636-19-2 N-(3-chloro-4-methoxy-1H-indol-7-yl)-4-nitro-benzenesulfonamide 
• 292636-25-0 N-(4-methoxy-1H-indol-7-yl)-4-nitro-benzenesulfonamide 

Relevant academic research and scientific papers

Field-based affinity optimization of a novel azabicyclohexane scaffold HIV-1 entry inhibitor

Small-molecule HIV-1 entry inhibitors are an extremely attractive therapeutic modality. We have previously demonstrated that the entry inhibitor class can be optimized by using computational means to identify and extend the chemotypes available. Here we demonstrate unique and differential effects of previously published antiviral compounds on the gross structure of the HIV-1 Env complex, with an azabicyclohexane scaffolded inhibitor having a positive effect on glycoprotein thermostability. We demonstrate that modification of the methyltriazole-azaindole headgroup of these entry inhibitors directly effects the potency of the compounds, and substitution of the methyltriazole with an amine-oxadiazole increases the affinity of the compound 1000-fold over parental by improving the on-rate kinetic parameter. These findings support the continuing exploration of compounds that shift the conformational equilibrium of HIV-1 Env as a novel strategy to improve future inhibitor and vaccine design efforts.

Rapid synthesis of diversely functionalized 3,4,7-trisubstituted indoles

Synthetic approaches are described for the synthesis of 4-alkoxyindole-7-carboxamides and 4-alkoxy-3-cyanoindole-7-carboxamides, which are useful intermediates in medicinal chemistry research. Two strategies were employed, highlighted by a Bartoli indole synthesis or a sequential and regioselective use of chlorosulfonyl isocyanate to install both the 3-cyano and 7-carboxamido groups. These routes are scalable and afford diversely functionalized indoles for further elaboration.

Methods and compounds for treating proliferative diseases

The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).

A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template. (C) 2000 Elsevier Science Ltd. All rights reserved.

Synthese de derives indoliques substitues in 7

The synthesis and some aspects of the chemical reactivity of 7-acetyl, 7-benzoyl and 7-bromoindoles are described.