81256-87-3

Basic information

• Product Name: 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine
• Synonyms: 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine;N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine;5'-DMT-2'-TBDMS-Bz-rC;N-(1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-((tert-butyldiMethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyriMidin-4-yl)benzaMide;2'-O-TBDMS-5'-O-DMT-N4-Bz cytidine;2'-O-t-ButyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-N4-benzyl cytidine;N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-[(1,1-diMethylethyl)diMethylsilyl]-Cytidine
• CAS NO: 81256-87-3
• Molecular Formula: C₄₃H₄₉N₃O₈Si
• Molecular Weight: 763.94996
• EINECS: 2017-001-1
• Mol File: 81256-87-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine(81256-87-3)
• EPA Substance Registry System: 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine(81256-87-3)

Safety Data

• Hazardous Substances Data: 81256-87-3(Hazardous Substances Data)

Usage

General Description

5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine is a type of chemical compound which is used in chemical and biochemical studies, particularly related to the field of synthetic organic chemistry. 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine, featuring a modified cytidine component, has been used in the production of potential therapeutic agents, such as antiviral drugs, due to its phosphate-masking features. It is also utilized in research involving oligonucleotide synthesis and chemical reactions that require controlled deprotection. The characteristic structure of 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine, includes Dimethoxytrityl (DMT), tert-Butyldimethylsilyl (TBDMS) protecting groups, and a Benzoyl (Bz) group attached to the Cytidine molecule.

Upstream product

• 16640-05-4 1-(β-D-arabinofuranosyl)-N⁴-benzoylcytosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 87418-76-6 N-(1-{(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide 
• 81246-76-6 4-N-benzoyl-1-(5-O-dimethoxytrityl-β-D-ribofuranosyl)cytosine 

Downstream Products

• 136044-35-4 N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)cytidine 3'-O-(2-cyanoethyl N,N-diethylphosphoramidite) 
• 81279-41-6 5'-dimethoxytrityl 2'-tert-butyldimethyl silyl N-benzoyl cytidine 3'-p-chlorophenyl β-cyanoethyl phosphotriester 
• 1134195-49-5 5'-O-dimethoxytrityl-N⁽⁴⁾-benzoyl-2'-O-(t-butyldimethylsilyl)cytidine-3'-O-(2-chlorophenylphosphate)-5'-O-2'-O-t-butyldimethylsilyburidine 
• 127578-31-8 5'-O-DMTr-2'-O-TBDMS-N-Bz-cytidine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt 
• 944137-51-3 C₇H₇O₃S^(1-)*C₃₂H₄₄N₅O₉Si⁽¹⁺⁾ 
• 944137-48-8 C₇H₇O₃S^(1-)*C₃₂H₄₄N₅O₉Si⁽¹⁺⁾ 
• 131289-16-2 N¹-benzoyl-2'-O-tert-butyldimethylsilyl-3'-O-succinyl-5'-O-dimethoxytrityl-cytidine 
• 944137-38-6 N¹-benzoyl-3'-O-tert-butyldimethylsilyl-2'-O-succinyl-5'-O-dimethoxytrityl-cytidine 
• 129395-59-1 C₄₈H₅₈N₅O₈PSSi 
• 86234-38-0 N-{1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 86234-45-9 N⁴-benzoyl-5'-O-dimethoxytrityl-3'-deoxyribicytidine 
• 118362-05-3 C₄₆H₅₈N₅O₁₄PSi*H₃N 
• 137760-81-7 C₄₃H₅₀N₃O₁₀PSi*C₆H₁₅N 
• 86314-30-9 Imidazole-1-carbothioic acid O-[(2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl] ester 

Relevant articles and documents

Practical silyl protection of ribonucleosides

Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows f

The preparation of protected arabinonucleosides

A general procedure is described for the preparation of protected arabinonucleosides.Protection at the 5'-position involves triphenylmethyl groups (DMT and MMT) while the tert-butyldimethylsilyl (TBDMS) group is used to protect the 2'- or 3'-positions.The

New catalists and procedures for the dimethoxytritylation and selective silylation of ribonucleosides

Procedures have been developed for the selective formation of (a) 2',5'-silylated ribonucleosides and (b) 3',5'-silylated ribonucleosides.These procedures also permit the selective silylation at either the 2'- or 3'-position of dimethoxytritylated ribonuc