812640-39-4Relevant academic research and scientific papers
THIAZOLE DERIVATIVES AS KINASE INHIBITORS
-
Page/Page column 54-55, (2008/12/05)
A series of thiazole derivatives which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
Integrating chemosensors for amine-containing compounds into cross-linked dendritic hosts
Mertz, Eric,Elmer, Stephanie L.,Balija, Amy M.,Zimmerman, Steven C.
, p. 11191 - 11204 (2007/10/03)
Trifluoroacetylazo dye 1, a known chemosensor for amines, has been integrated into cross-linked dendrimer hosts. Thus, boronic acid 16 was linked to iododye 9 via a Suzuki coupling reaction. In situ deprotection and alkylation with dendrons 3 and 4, conta
Cross-linked dendrimer hosts containing reporter groups for amine guests
Mertz, Eric,Zimmerman, Steven C.
, p. 3424 - 3425 (2007/10/03)
The integration of a chromogenic reporter group into the recently reported (Zimmerman, S. C.; Wendland, M. S.; Rakow, N. A.; Zharov, I.; Suslick, K. S. Nature 2002, 418, 399-403) monomolecular imprinting approach is described. The resulting highly cross-linked, macromolecular hosts show rapid, selective, high affinity, two-point binding of straight-chain diamine guests. Over longer times, the hosts are more promiscuous, binding a broader range of diamines. A rigorous test of imprinting was performed wherein the cross-reactivities of two dendrimers derived from different templates are compared. The test reveals a guest-dependent kinetic binding effect masquerading as evidence of a highly selective two-point imprinting process. Copyright
