81281-85-8

Basic information

• Product Name: 4H-1-Benzopyran-4-one,2-phenyl-3-(1-piperidinyl)-(9CI)
• Synonyms: 4H-1-Benzopyran-4-one,2-phenyl-3-(1-piperidinyl)-(9CI)
• CAS NO: 81281-85-8
• Molecular Formula: C₂₀H₁₉NO₂
• Molecular Weight: 305.37036
• Product Categories: FLAVONE
• Mol File: 81281-85-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 451.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.229±0.06 g/cm3(Predicted)
• PKA: 2.02±0.20(Predicted)
• CAS DataBase Reference: 4H-1-Benzopyran-4-one,2-phenyl-3-(1-piperidinyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one,2-phenyl-3-(1-piperidinyl)-(9CI)(81281-85-8)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one,2-phenyl-3-(1-piperidinyl)-(9CI)(81281-85-8)

Safety Data

• Hazardous Substances Data: 81281-85-8(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 1025-86-1 3-bromo-2-phenyl-chromen-4-one 
• 525-82-6 FLAVONE 
• 67139-31-5 trans-3-mesyloxyflavanone 
• 81281-80-3 (2S,3S)-2-Phenyl-3-piperidin-1-yl-chroman-4-one 

Relevant articles and documents

Buchwald-Hartwig reactions of monohaloflavones

The article describes the amination of different monobromo- or monochloroflavones with primary and secondary alkylamines and aniline derivatives by Buchwald-Hartwig reaction. The influence of the phosphine ligands used is described. The use of amino acid derivatives as a nitrogen source is also demonstrated. This latter reaction allows the synthesis of unique flavone-amino-acid conjugates.

FLAVONOIDS, XXXVI REACTION OF 3-ALKYL- OR -ARYLSULFONYLOXYFLAVANONES WITH AMINES. SYNTHESIS OF 3-DIALKYLAMINOFLAVANONES

Reactions of 3-alkyl- or -arylsulfonyloxyflavanones (1a-h) with primary and tertiary amines gave mixtures of the corresponding flavones (2a-d) and aurones (3a-d), while with secondary amines, in addition to 2 and 3, 3-dialkylaminoflavanones (6-9) were also obtained.The factors which determine the ratio of products are discussed.Treatment of the 3-dialkylaminoflavones 6a and 7 with DDQ gave 3-dialkylaminoflavanones (10, 11); treatment with alkali in methanol afforded 2-dialkylamino-2-benzylcoumaran-3-ones (12, 13).