1025-86-1

Upstream product

• 525-82-6 FLAVONE 
• 107943-75-9 3,3-dibromoflavanone 
• 88187-08-0 2-acetoxy-3-bromoflavan-4-one 
• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 109365-86-8 1-(o-hydroxyphenyl)-3-phenylpropargylic alcohol 
• 536-74-3 phenylacetylene 
• 90-02-8 salicylaldehyde 
• 122-79-2 Phenyl acetate 
• 4010-33-7 2-acetylphenyl benzoate 
• 39103-33-8 3-hydroxy-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 98-88-4 benzoyl chloride 
• 245322-93-4 1-(2-methoxyphenyl)-3-phenylprop-2-yn-1-ol 
• 135-02-4 ortho-anisaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 81281-86-9 3-(4'-morpholinyl)flavone 
• 955880-05-4 C₂₁H₂₁BO₄ 
• 1373355-57-7 5-phenyl-5H-benzo[c]xanthen-7(6H)-one 
• 1446428-44-9 3-(3-hydroxy-3-methyl-1-butynyl)flavone 
• 1446428-43-8 3-(2-(trimethylsilyl)ethynyl)flavone 
• 1048823-50-2 C₂₂H₁₆O₂ 
• 1047526-35-1 C₂₂H₁₆O₃ 
• 1363396-02-4 C₂₃H₁₆O₂ 
• 1048581-79-8 3-(4-chlorophenyl)-2-phenyl-4H-chromen-4-one 
• 1017073-56-1 C₂₁H₁₃ClO₂ 
• 1363396-03-5 C₂₁H₁₃FO₂ 
• 1048750-53-3 C₂₂H₁₃F₃O₂ 
• 1363396-04-6 C₂₁H₁₃NO₄ 
• 1363396-05-7 C₂₂H₁₆O₂S 

Relevant academic research and scientific papers

A novel and one step procedure for preparation of α-bromo-α,β-unsaturated carbonyl compounds

A new one step method is developed for the preparation of α-bromo-α,β-unsaturated carbonyl compounds in moderate to good yields from corresponding α,β-unsaturated carbonyl compounds using DMP [1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(IH)-one] and te

A selective transformation of flavanones to 3-bromoflavones and flavones under microwave irradiation

This paper presents the first report of a highly selective transformation of flavanones to 3-bromoflavones or flavones by microwave irradiation of the corresponding flavanone reactants and N-bromosuccinimide (NBS) in the presence of a catalytic amount of 2,2′-azobis(isobutyronitrile) (AIBN). The combination of good to excellent yields, shorter reaction time (10 min), and high levels of functional group compatibility make this an attractive synthetic approach to 3-bromoflavones and flavones.

Synthesis of 1,3-thioxoketones from salicylaldehyde

A method for the synthesis of monothiodibenzoylmethanes was developed. The method involves a reaction of potassium thioacetate with 1-(2-hydroxyphenyl)-3- phenylpropynone prepared from salicylaldehyde.

An efficient synthesis of 3-bromoflavones under solvent free conditions using grinding technique

Selective bromination of 1-(2-hydroxyphenyl)-3-phenylpropane- 1,3-diones has been carried out with ammonium bromide and ammonium persulphate at room temperature using grinding technique under solvent free conditions to give 2-bromo derivatives which on cyclodehydration with p-toluenesulphonic acid under grinding conditions give 3-bromoflavones. Also, flavones on bromination using above mentioned conditions give 3-bromoflavones directly.

A new synthesis of 5-arylbenzo[c]xanthones from photoinduced electrocyclisation and oxidation of (E)-3-styrylflavones

A new synthetic route to 5-arylbenzo[c]xanthones is -established. This was accomplished by use the Heck reaction of 3-bromoflavones with styrene derivatives, leading to (E)-3-styrylflavones with total diastereoselectivity. This transformation was greatly improved under microwave irradiation. The one-pot, photoinduced electrocyclisation of (E)-3-styrylflavones and further in situ oxidation of the cycloadduct leads to 5-arylbenzo[c]xan-thones. Georg Thieme Verlag Stuttgart · New York.

A new synthesis of novel alkenylated flavones by palladium-catalyzed cross-coupling reactions

Bromoflavones were treated with various terminal alkynes in palladium-catalyzed cross-coupling reactions under phosphine-free condions to give the expected alkenylated flavones in moderate to good yields. The presence of two different β hydrogens in the t

Facile synthesis of new substituted 3-aryl/heteroarylflavones by Suzuki-Miyaura coupling of 3-bromoflavone with substituted aryu heteroarylboronic acids

Flavones 7a-k having aryl and heteroaryl substituents at 3-position were synthesized in a Panasonic microwave-oven by Suzuki-Miyaura cross coupling reaction using 3-bromoflavone 5 and substituted aryl and heteroaryl boronic acids 6a-k with tetrakistriphenylphospine-palladium |(C6H 6)3P]4Pd as catalyst and N,N-dimethylformamide (DMF)+ H2O (9:4) as solvent, and aq.Na2CO3(2N) as base.

PHARMACEUTICAL COMPOUNDS

The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.

New synthesis of 3-bromoflavones via bromination of 1-(2-hydroxyphenyl)-3- arylpropane-1,3-dione by CuBr2, and conversion into 3-aminoflavones

A new synthesis of 3-bromoflavones from 1-(2-hydroxyphenyl)-3-arylpropane- 1,3-dione using CuBr2 is described. The usefulness of 3-bromoflavone as a precursor of 3-aminoflavone is also described. Copyright

Microwave enhanced palladium catalysed coupling reactions: A diversity-oriented synthesis approach to functionalised flavones

Microwave enhanced diversity-oriented synthesis (MEDOS) using palladium catalysed protocols is introduced as a powerful new strategy for the synthesis of systematically modified small molecules and is highlighted by application to functionalised flavones. The Royal Society of Chemistry 2006.