81281-86-9Relevant academic research and scientific papers
Synthesis of 3-N-Substituted Aminoflavones as Potential CNS Agents
Kapoor, R. P.,Rastogi, M. K.,Garg, C. P.
, p. 285 - 286 (2007/10/02)
3-N-Substituted aminoflavones (VI) have been synthesized by the action of appropriate secondary amines on 3-bromoflavone (III).In the preparation of III by a known procedure involving the bromination of flavone (II), a mixture of three products has been obtained rather than one product as reported by Pendse .The structures of VI and two of the bromination products have been established on the basis of their elemental analyses and spectral data.Compounds VI exhibit weak CNS depressant, hypotensive and hyperthermic activities.
FLAVONOIDS, XXXVI REACTION OF 3-ALKYL- OR -ARYLSULFONYLOXYFLAVANONES WITH AMINES. SYNTHESIS OF 3-DIALKYLAMINOFLAVANONES
Patonay, T.,Litkei, Gy.,Bognar, R.
, p. 135 - 146 (2007/10/02)
Reactions of 3-alkyl- or -arylsulfonyloxyflavanones (1a-h) with primary and tertiary amines gave mixtures of the corresponding flavones (2a-d) and aurones (3a-d), while with secondary amines, in addition to 2 and 3, 3-dialkylaminoflavanones (6-9) were also obtained.The factors which determine the ratio of products are discussed.Treatment of the 3-dialkylaminoflavones 6a and 7 with DDQ gave 3-dialkylaminoflavanones (10, 11); treatment with alkali in methanol afforded 2-dialkylamino-2-benzylcoumaran-3-ones (12, 13).
