81286-42-2

Upstream product

• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 106-40-1 4-bromo-aniline 
• 106-49-0 p-toluidine 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 75-15-0 carbon disulfide 

Downstream Products

• 28250-84-2 2-(4-bromo-phenylimino)-5-methyl-3-p-tolyl-thiazolidin-4-one 
• 1381877-46-8 4-(4-bromophenyl)-N-p-tolyl-4H-1,2,4-triazol-3-amine 
• 1381877-35-5 N-(4-bromophenyl)-4-p-tolyl-4H-1,2,4-triazol-3-amine 
• 85063-54-3 (N-(4-bromophenyl)-6-methylbenzo[d]thiazol-2-amine) 

Relevant academic research and scientific papers

A simple and straightforward synthesis of phenyl isothiocyanates, symmetrical and unsymmetrical thioureas under ball milling

Promoted by KOH under ball milling, anilines were efficiently transformed into isothiocyanates (in presence of 5.0 equiv. CS2) or symmetrical thioureas (in presence of 1.0 equiv. CS2), without using any other harsh or toxic decomposition reagent. Some in situ generated isothiocyanates can directly "click" with other amines to afford unsymmetrical thioureas.

A new and efficient solid state synthesis of diaryl thioureas

Fourteen diaryl thioureas which are physiologically active have been synthesized in the solid state at room temperature. The reaction needs only simple equipment and gives excellent yields.