81303-52-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate serves as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, leveraging its carboxylate ester functional group to facilitate the creation of bioactive molecules.
Used in Antifungal and Antimicrobial Applications:
ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate is utilized for its inherent antifungal and antimicrobial properties, making it a valuable asset in the development of treatments and preventive measures against fungal and microbial infections.
Used in Corrosion Inhibition:
Ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate has been studied for its potential as a corrosion inhibitor, offering a protective layer on metal surfaces and extending their durability and lifespan in various industrial applications.
Used in Medicinal Chemistry and Drug Discovery:
Its unique chemical properties make it an indispensable component in the fields of medicinal chemistry and drug discovery, where it contributes to the design and synthesis of novel therapeutic agents.
Used in Chemical Engineering:
In chemical engineering, ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate plays a crucial role in the development of new chemical processes and the improvement of existing ones, particularly in the synthesis of complex organic compounds.

Upstream product

• 81303-65-3 4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid 

Downstream Products

• 1380330-03-9 1-methyl-5-(2-phenylimidazo[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1278406-88-4 4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-phenylimidazo[1,2-a]pyridin-7-yl)amide 
• 1278406-65-7 2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-[(2-phenylimidazo[1,2-a]pyridin-7-yl)amide] 
• 1380329-78-1 4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)amide 
• 1380329-86-1 2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-[(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)amide] 
• 1278406-72-6 1-methyl-5-(2-phenylimidazo[1,2-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Palladium-Catalyzed C-N Coupling of Pyrazole Amides with Triazolo- And Imidazopyridine Bromides in Ethanol

An efficient palladium-catalyzed coupling between a pyrazole amide and a heteroaryl bromide was developed to enable the streamlined synthesis of a lead candidate for schizophrenia treatment. Process robustness and scalability were achieved using ethanol a

Pd-CATALYZED COUPLING OF PYRAZOLE AMIDES

A novel process for the preparation of imidazo[1,2-a]pyridine compounds of the formula (I), wherein R1 is C1-4-alkoxy or NR4R5 wherein R4 and R5 are independently hydrogen or C1-4-alkyl or R4 and R5, together with the nitrogen atom to which they are attached, form a saturated 4- to 6-membered heterocyclic ring which may contain one further heteroatom selected from nitrogen or oxygen; R2 is C1-4-alkyl, C1-4-alkoxycarbonyl, halogen, phenyl which is optionally substituted with C1-4-alkyl, C1-4-alkoxy or halogen or is NR4R5 wherein R4 and R5 are independently hydrogen or C1-4-alkyl or R4 and R5, together with the nitrogen atom to which they are attached, form a saturated 4- to 6-membered heterocyclic ring which may contain one further heteroatom selected from nitrogen or oxygen; R3 is C1-4-alkyl and X is nitrogen or CH is described. The imidazo[1,2-a]pyridine compounds of the formula (I) are either precursors for active principles or active principles itself, acting as phosphodiesterase (PDE) inhibitors, particularly PDE10 inhibitors which have the potential to treat psychotic disorders like schizophrenia (Int. Patent Publication WO 2012/076430).