ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate

Base Information

• Chemical Name: ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate
• CAS No.: 81303-52-8
• Molecular Formula: C₈H₁₁N₃O₃
• Molecular Weight: 197.194
• Hs Code.: 2933199090
• Mol file: 81303-52-8.mol

Synonyms:ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate;5-(Aminocarbonyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Chemical Property of ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate

Chemical Property:

• PSA: 87.21000
• LogP: 0.39600
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-carbamoyl-1-methyl-1H-pyrazole-4-carboxylate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate

There total 1 articles about ethyl 5-carbaMoyl-1-Methyl-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (81303-65-3) → ethyl 5-carbamoyl-1-methyl-1H-pyrazole-4-carboxylate (81303-52-8)

Guidance literature:

With ammonia; 1,1'-carbonyldiimidazole; In 2-methyltetrahydrofuran; at 20 ℃;

DOI:10.1021/acs.oprd.0c00437

Reference yield: 97.0%

7-bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine (947533-55-3) + ethyl 5-carbamoyl-1-methyl-1H-pyrazole-4-carboxylate (81303-52-8) → 5-[(2-(4-fluorophenyl)-imidazo[1,2-a]pyridin-7-yl)carbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethanol; at 80 ℃; for 3h; Inert atmosphere;

Reference yield: 93.0%

7-bromo-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine (1380331-12-3) + ethyl 5-carbamoyl-1-methyl-1H-pyrazole-4-carboxylate (81303-52-8) → 1-methyl-5-(2-phenylimidazo[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester (1380330-03-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethanol; at 20 - 74 ℃; for 20.5h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; Large scale;

DOI:10.1021/acs.oprd.0c00437

upstream raw materials:

4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid

Downstream raw materials:

1-methyl-5-(2-phenylimidazo[1,2-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester

1-methyl-5-(2-phenylimidazo[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester

4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-phenylimidazo[1,2-a]pyridin-7-yl)amide

2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-[(2-phenylimidazo[1,2-a]pyridin-7-yl)amide]

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