813445-24-8

Upstream product

• 813445-23-7 ((7R,8R)-7-Hydroxymethyl-1,4-dioxa-spiro[4.5]dec-8-yl)-carbamic acid benzyl ester 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 813445-21-5 [(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol 
• 813445-19-1 ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate 
• 813445-20-4 (7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid ethyl ester 
• 14160-65-7 ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate 

Downstream Products

• 852661-23-5 C₂₇H₃₅FN₂O₄ 
• 852661-42-8 benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate 
• 852661-25-7 C₂₀H₃₂FN₃O 
• 852661-47-3 N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide 
• 852661-44-0 benzyl (1R,2S)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-oxocyclohexylcarbamate 
• 852661-24-6 C₂₈H₃₈FN₃O₃ 
• 852661-45-1 benzyl (1R,2S,4R)-4-amino-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexylcarbamate 
• 852661-30-4 N-{(1R,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[4-methyl-1,3-thiazol-2-yl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide 
• 852661-31-5 N-{(1S,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[4-methyl-1,3-thiazol-2-yl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide 
• 852661-28-0 N-{(1R,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[1-methyl-indazol-5-yl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide 
• 852661-29-1 N-{(1S,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[1-methyl-indazol-5-yl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide 
• 852661-46-2 benzyl (1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexylcarbamate 
• 852661-43-9 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(1,3,4-thiadiazol-2-yl)urea 
• 852661-21-3 N-((1R,3S,4R)-4-({[(5-acetyl-4-methyl-1,3-thiazol-2-yl)amino]carbonyl}amino)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N-methylacetamide 

Relevant academic research and scientific papers

N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present application describes modulators of chemokine receptors of formula (I), or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

Process of preparing N-ureidoalkyl-piperidines

The present application describes a process of preparing a compound of formula (IV), or salt or stereoisomer thereof: wherein Pg, at each occurrence, is independently selected from an amine protecting group; comprising the steps of reacting a compound of Formula with a reducing agent to give a compound of Formula III: reacting the compound of formula (III) with an amine of formula (IIa) using reductive amination to give the compound of formula (III)

N-ureidoalkyl-piperidines as modulators of chemokine receptor activity

The present application describes modulators of chemokine receptor activity of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases, as well as autoimmune pathologies such as rheum